Nov 16, 2025 1:00 PM EST

Week 11

Tampa Bay

6-3

Buffalo

BUF

-5½ (-110)o48½ (-110)

CBS

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Buffalo Bills vs Tampa Bay Buccaneers Betting Trends

Updated:Nov 13, 2025 1:11 AM EST

The upcoming Sunday football game on November 16, 2025, between the Buffalo Bills and Tampa Bay Buccaneers at Highmark Stadium in Orchard Park, NY, is set to be an intense NFL regular season Week 11 battle. Buffalo Bills, led by starting quarterback Josh Allen, bring a strong offensive game with an average of 231.2 passing yards and 153.2 rushing yards per game. Meanwhile, the Buccaneers, with Baker Mayfield at quarterback, average 228.6 passing yards and 99.8 rushing yards, presenting a balanced attack.

Buffalo's pass protection, ranked higher than Tampa Bay's pass rush, could give Allen more time to connect with his receivers, including the questionable but likely playing Khalil Shakir. Tampa Bay's defense has been solid, but the Bills' offensive stats and strong home record (4-1) give them an edge in this matchup. Tampa's pass offense versus Buffalo's pass defense will be a key battle, with Tampa's 233.2 passing yards facing Buffalo's 170.2 allowed yards.

The Buccaneers have some injury concerns, including Mike Evans on IR and other questionable players, which could impact their offensive rhythm. The Bills also have some key players questionable but expect most to play. The point spread favors the Bills at -5.5, and the total points are set at 48, indicating a moderately high-scoring game. These betting trends and game insights provide valuable information for making an informed wager.

In their last matchup on August 23, 2025, the Buffalo Bills defeated the Tampa Bay Buccaneers 23-19 in a preseason game, showing the Bills' ability to edge out close contests. The Bills are favored to win again with the best odds available at Caesars sportsbook. The best odds available today for Buffalo is -5.5 at Caesars and for Tampa Bay +5.5 at Caesars.

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ATS Records

Tampa Bay

Buffalo

All

All
1st half
2nd half
1st quarter
2nd quarter
3rd quarter
4th quarter

5-4 (9th)Against the Spread4-5 (19th)

6-3 (11th)Straight Up6-3 (8th)

+2.0Straight Up Units0.0

5-4Over / Under4-5

TEAM MATCHUP

Tampa Bay

Buffalo

OFF

DEF

OFF

DEF

24.4Points27.6

11.4First Half12.3

13Second Half15.2

3.3First Quarter6.1

8.1Second Quarter6.2

7.6Third Quarter7.2

5.4Fourth Quarter8

328.3Total Yards384.4

5.5Yards Per Play6.6

228.6Passing Yards231.2

22.2 - 34.7 (64.1%)Completions-Attempts20.9 - 29.9 (69.9%)

6.2Yards Per Passing Play7.2

2.1 (15)Sacks (Yards)2.2 (12)

99.8Rushing Yards153.2

25Attempts30.9

4Yards Per Rush5

19.41st Downs22.8

11.1Passing12

6Rushing8.3

2.3Penalties2.4

4.7 / 12.8 (36.5%)3rd Down5.2 / 11.9 (43.9%)

0.7 / 1.4 (46.2%)4th Down0.4 / 0.9 (50%)

1.4 / 2.8 (52%)Red Zone2.3 / 3.6 (65.6%)

6.2 (48.6)Penalties (Yards)6.8 (57.6)

1.2Turnovers1.1

0.9Interceptions0.7

0.3Fumbles Lost0.4

61.8Total Plays63

5.2Kickoffs5.6

3.9Returns4

94.3Return Yards101.4

24.3Yards Per Return25.4

4.2Punts3.2

1.9Returns1.9

24.3Return Yards11

12.9Yards Per Return5.8

Priority Injuries

Tampa Bay

Buffalo

PRIORITY

Chris Godwin Jr.

Doubtful

Est. Return Nov 16, 2025

14 Wide Receiver

a day ago

PRIORITY

Bucky Irving

Doubtful

Est. Return Nov 16, 2025

7 Running Back

a day ago

PRIORITY

Mike Evans

Injury Reserve

Est. Return Dec 21, 2025

13 Wide Receiver

22 days ago

No priority injuries for this team

HEAD TO HEAD

Tampa Bay

Buffalo

BUF

NFL

ODDS PICKS PLAYER PROPS FUTURES PLAYER FUTURES INJURIES WEATHER RANKINGS STANDINGS

Spread

Spread
Money
Total
Merged

Game

Game
1H
2H
1Q
2Q
3Q
4Q

This Week

Last Week

Personalize your notifications and get updates on the teams, players or events you care about most. THU 11/138:15 PM N.Y. Jets 2-7 75% +13 -105BetMGM
New England 8-2 25% -12½ -118FanDuel
Personalize your notifications and get updates on the teams, players or events you care about most. SUN 11/169:30 AM Washington 3-7 33% +2½ +100Caesars
Miami 3-7 67% -2½ -115Bet365
Personalize your notifications and get updates on the teams, players or events you care about most. SUN 11/161:00 PM Green Bay 5-3-1 36% -7 -110Caesars
N.Y. Giants 2-8 64% +7 -104FanDuel
Personalize your notifications and get updates on the teams, players or events you care about most. SUN 11/161:00 PM Tampa Bay 6-3 41% +5½ -107Caesars
Buffalo 6-3 59% -5½ -110Bet365
Personalize your notifications and get updates on the teams, players or events you care about most. SUN 11/161:00 PM Cincinnati 3-6 35% +5½ -107Caesars
Pittsburgh 5-4 65% -5½ -110Bet365
Personalize your notifications and get updates on the teams, players or events you care about most. SUN 11/161:00 PM Houston 4-5 22% -6 -110Bet365
Tennessee 1-8 78% +7 -117SugarHouse
Personalize your notifications and get updates on the teams, players or events you care about most. SUN 11/161:00 PM Chicago 6-3 71% +3 -125BetMGM
Minnesota 4-5 29% -2½ -115Caesars
Personalize your notifications and get updates on the teams, players or events you care about most. SUN 11/161:00 PM Carolina 5-5 80% +3½ -110FanDuel
Atlanta 3-6 20% -3½ -105Bet365
Personalize your notifications and get updates on the teams, players or events you care about most. SUN 11/161:00 PM L.A. Chargers 7-3 54% -3 -105Caesars
Jacksonville 5-4 46% +3 -114BetRivers
Personalize your notifications and get updates on the teams, players or events you care about most. SUN 11/164:05 PM Seattle 7-2 46% +3 -109Caesars
L.A. Rams 7-2 54% -3 -109BetRivers
Personalize your notifications and get updates on the teams, players or events you care about most. SUN 11/164:05 PM San Francisco 6-4 25% -3 +100Bet365
Arizona 3-6 75% +3 -102Caesars
Personalize your notifications and get updates on the teams, players or events you care about most. SUN 11/164:25 PM Baltimore 4-5 15% -7½ -109Caesars
Cleveland 2-7 85% +8 -117SugarHouse
Personalize your notifications and get updates on the teams, players or events you care about most. SUN 11/164:25 PM Kansas City 5-4 30% -3½ -110Bet365
Denver 8-2 70% +4 -114BetRivers
Personalize your notifications and get updates on the teams, players or events you care about most. SUN 11/168:20 PM Detroit 6-3 27% +2½ +100Caesars
Philadelphia 7-2 73% -2½ -114FanDuel
Personalize your notifications and get updates on the teams, players or events you care about most. MON 11/178:15 PM Dallas 3-5-1 9% -3½ -102BetMGM
Las Vegas 2-7 91% +3½ -114Caesars

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Buffalo Bills vs Tampa Bay Buccaneers Betting Trends

ATS Records

Tampa Bay

Buffalo

TEAM MATCHUP

Tampa Bay

Buffalo

Priority Injuries

Tampa Bay

Buffalo

Recent Results

Tampa Bay

Buffalo

HEAD TO HEAD

Tampa Bay

Buffalo

Tampa Bay

UPCOMING SCHEDULE

Buffalo