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The upcoming NFL Week 16 clash on December 21, 2025, between the Tampa Bay Buccaneers and Carolina Panthers at Bank of America Stadium in Charlotte, NC, is set to be an exciting Sunday football event. Fans can catch the action live on FOX as these two teams battle it out. The current odds favor the Tampa Bay Buccaneers with a point spread of -3 -106, down slightly from the opening odds, indicating some confidence in their ability to cover the spread. Meanwhile, the Carolina Panthers sit at +3 -114, providing an enticing underdog opportunity.
Betting lines reveal a total over/under of 45½, with the under at -112 being the favorite. This suggests that bettors might expect a defensive showdown. The Tampa Bay Buccaneers are the favorites with moneyline odds of -162, while the Panthers are underdogs at +135. Watching how these odds shift can help bettors make smarter wagers, as movement often reflects insider knowledge or betting trends.
For bettors looking to dive deeper, the NFL odds page offers comprehensive insights and updates. Ready to bet smarter? Start your OddsTrader Turbo subscription now or place your bet with a U.S. regulated sportsbook and profit off the edge.
Seattle 11-355% -1½ -108FanDuel | |||||||
![]() Washington 4-1085% +6½ -110Caesars | |||||||
![]() Chicago 10-446% +1½ -120FanDuel | |||||||
Cleveland 3-1143% +10½ -114Caesars | |||||||
New Orleans 4-1088% -4½ -110Bet365 | |||||||
![]() N.Y. Giants 2-1249% +3 -113Caesars | |||||||
Carolina 7-787% +3 -110Bet365 | |||||||
![]() Tennessee 2-1286% +3 -105Bet365 | |||||||
Dallas 6-7-142% -2 -110Bet365 | |||||||
Miami 6-866% +4½ -110BetRivers | |||||||
Arizona 3-1127% +3 -113Caesars | |||||||
Denver 12-257% -3 -110Bet365 | |||||||
Detroit 8-66% -6½ -120FanDuel | |||||||
![]() Houston 9-542% -14 -108BetRivers | |||||||
![]() Baltimore 7-769% -2½ -121SugarHouse | |||||||
![]() Indianapolis 8-684% +6½ -110BetMGM |
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