Chicago Bears vs San Francisco 49ers Betting Trends

The upcoming NFL showdown on December 28, 2025, between the Chicago Bears and San Francisco 49ers at Levi's Stadium in Santa Clara, CA, is set to be a thrilling Sunday night football event. The Bears will rely on quarterback Caleb Williams, who has shown resilience despite some injury concerns. Meanwhile, the 49ers will start Brock Purdy, who has been a consistent offensive force for the team.

Analyzing the betting trends, the 49ers are favorites with a -3 point spread and a total points line set at 51.5. The Bears have a solid away record of 5-3 ATS, while the 49ers hold a 3-3 ATS record at home. This game promises a strategic battle, with the Bears boasting a strong pass offense averaging 219.4 yards per game, facing the 49ers' pass defense that allows 229.3 yards. The 49ers counter with a robust run offense at 104.3 yards per game against the Bears' run defense giving up 131 yards on average.

Pass protection and pass rush will be key factors, with the Bears allowing 10.5 sacks and the 49ers 9.5 sacks this season. The Bears' defense has been effective in limiting scoring, holding opponents to under 25 points in recent games, while the 49ers have a dynamic scoring offense averaging 26 points per game. Injuries to key players like Joe Tryon-Shoyinka (questionable) for the Bears and Yetur Gross-Matos (questionable) for the 49ers could impact defensive plays.

In their last matchup on December 8, 2024, the 49ers dominated the Bears 38-13 at Levi's Stadium, a game where the 49ers covered the spread comfortably. Bettors should consider the 49ers' home advantage and recent form when placing wagers. The best odds today for Chicago are +3 -109 and for San Francisco -3 -110 at Caesars. For those looking to sharpen their betting strategy, Start your OddsTrader Turbo subscription or place your bet with a U.S. regulated sportsbook and profit off the edge.