Chicago Bears vs San Francisco 49ers Betting Trends

The upcoming NFL clash on December 28, 2025, between the Chicago Bears and San Francisco 49ers at Levi's Stadium in Santa Clara, CA, is set to be a thrilling Sunday night football event broadcasted on NBC and NBC/Peacock. The San Francisco 49ers enter as favorites with a -3.5 point spread and the total points over/under set at 52.5, indicating a potentially high-scoring game.

Starting quarterbacks Brock Purdy for the 49ers and Tyson Bagent for the Bears will be key figures. Purdy leads a strong passing offense averaging 249.4 yards per game, facing a Bears defense allowing 217.1 passing yards. The Bears' offense, led by Bagent, averages 219.4 passing yards but faces a tough 49ers defense allowing just 229.3 passing yards per game, slightly better than the Bears’ defense.

On the ground, the Bears average 152.1 rushing yards per game versus the 49ers' 104.3 rushing yards allowed, suggesting Chicago may try to exploit their running game. Defensive lineups and pass rushes are critical, with the 49ers recording fewer sacks allowed (9.5 yards lost) compared to the Bears (11.8 yards lost), indicating a slight edge in pass protection for San Francisco.

Recent performances favor the 49ers, who have won their last three games comfortably, including a 48-27 victory over the Colts. The Bears have also been solid, winning four of their last five games. Injuries to key players like George Kittle (questionable) for the 49ers and Josh Blackwell (questionable) for the Bears may influence the game dynamics.

The Bears have a strong away record of 5-3 straight up and against the spread, while the 49ers have a 4-2 home record, reflecting balanced competitiveness. The last matchup on December 8, 2024, saw the 49ers dominate 38-13 at Levi's Stadium, which could psychologically impact this Week 17 showdown.

Using these betting trends and game insights, bettors should consider the 49ers' home advantage and superior recent form. The point spread and total points suggest a wager on the 49ers covering the spread and the game going over 52.5 points could be smart bets. Ready to bet smarter? Start your OddsTrader Turbo subscription now or place your bet with a U.S. regulated sportsbook and profit off the edge.