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The upcoming Sunday football game on December 21, 2025, between the Jacksonville Jaguars and Denver Broncos at Empower Field at Mile High in Denver, CO, promises an exciting NFL Week 16 matchup. The Broncos will host the Jaguars with quarterback Bo Nix likely starting for Denver, while Jacksonville will have Trevor Lawrence leading their offense. Lawrence's passing offense ranks slightly higher than Denver's defense, but Denver's pass protection is solid against Jacksonville's pass rush, making for a balanced aerial battle.
On the ground, Jacksonville boasts a stronger run offense compared to Denver's run defense, which could influence the game's tempo and scoring opportunities. Denver's offense has been effective, averaging 24.43 points per game, while Jacksonville scores around 26.86 points. Defensively, Denver allows fewer points, creating a tight contest likely to stay under the 47-point total set by sportsbooks.
Denver holds a home record of 7-0 SU and 4-3 ATS, while Jacksonville is 4-2 SU on the road with a 3-3 ATS away record. The point spread currently favors Denver by 3.5 points, with the total at 47 points. This suggests a close game where betting trends indicate a slight edge for Denver to cover the spread. The last matchup on October 30, 2022, saw Denver narrowly win 21-17 in London, a game that went under 40.5 points.
This game will be broadcast on FOX, offering fans and bettors live access to all the action. Key players like Trevor Lawrence and Bo Nix's performances against each other's defenses will be crucial. Injuries are minimal, with Denver's John Franklin-Myers questionable but likely to play, and Jacksonville's Josh Hines-Allen questionable as well.
Understanding these betting trends and game insights can help bettors make informed decisions. The Broncos' strong home performance and the close point spread make Denver a smart best bet, but Jacksonville's potent run game and solid ATS record keep this matchup competitive.
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![]() Washington 4-1084% +7 -110Caesars | |||||||
![]() Chicago 10-450% -1 -115SugarHouse | |||||||
Cleveland 3-1155% +10½ -113BetRivers | |||||||
New Orleans 4-1082% -5½ -118FanDuel | |||||||
![]() N.Y. Giants 2-1256% +3 -113Caesars | |||||||
Carolina 7-777% +3 -110Bet365 | |||||||
![]() Tennessee 2-1287% +3 -105BetMGM | |||||||
Dallas 6-7-154% -2 -106Caesars | |||||||
Miami 6-867% +4½ -117SugarHouse | |||||||
Arizona 3-1130% +3 -110Caesars | |||||||
Denver 12-246% -3 -115BetMGM | |||||||
Detroit 8-68% -6½ -120FanDuel | |||||||
![]() Houston 9-533% -14 -110Caesars | |||||||
![]() Baltimore 7-764% -2½ -121SugarHouse | |||||||
![]() Indianapolis 8-683% +6 -110Bet365 | |||||||
Seattle 12-338 -1 -115SugarHouse |
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