Nov 23, 2025 1:00 PM EST

Week 12

N.Y. Giants

6-4

Detroit

DET

-13 (-110)o50½ (-110)

FOX

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N.Y. Giants vs Detroit Lions Picks Week 12

Updated:Nov 23, 2025 1:26 AM EST

The upcoming NFL regular season Week 12 game between the N.Y. Giants and Detroit Lions is set for November 23, 2025, at Ford Field in Detroit, MI. This Sunday football matchup promises high excitement and strategic gameplay. The game will be broadcast on Fox, providing fans and bettors prime viewing access.

Our picks and betting tips favor the Detroit Lions with a predicted score of 29 against the N.Y. Giants' 19. The Lions are expected to cover a -12.5 point spread, reflecting their strong form this season. Our prediction model has shown a solid hit rate of 58.3% on point spreads for the Giants and an impressive 80.6% on 2-way markets for Detroit, indicating high expected value (EV) and profitable betting opportunities in these markets.

With a predicted total score close to 49 points, bettors should consider the under 50.5 points market, which has a positive EV of 0.7% and a 53.1% hit rate, suggesting a smart betting decision. These insights can guide bettors to make informed wagers for this NFL game.

For more comprehensive analysis and expert picks, visit our NFL picks and predictions page. Ready to bet smarter? Start your OddsTrader Turbo subscription now or place your bet with a U.S. regulated sportsbook and profit off the edge.

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Personalize your notifications and get updates on the teams, players or events you care about most. SUN 11/231:00 PM Pittsburgh 6-4 53% +2½ -105Bet365
Chicago 7-3 47% -2½ -114Caesars
Personalize your notifications and get updates on the teams, players or events you care about most. SUN 11/231:00 PM N.Y. Jets 2-8 75% +13½ -105Bet365
Baltimore 5-5 25% -13½ -110BetMGM
Personalize your notifications and get updates on the teams, players or events you care about most. SUN 11/231:00 PM N.Y. Giants 2-9 89% +13½ -115Caesars
Detroit 6-4 11% -12½ -115SugarHouse
Personalize your notifications and get updates on the teams, players or events you care about most. SUN 11/231:00 PM New England 9-2 55% -7½ -109Caesars
Cincinnati 3-7 45% +7½ -110Caesars
Personalize your notifications and get updates on the teams, players or events you care about most. SUN 11/231:00 PM Seattle 7-3 12% -12 -110Bet365
Tennessee 1-9 88% +12½ -105FanDuel
Personalize your notifications and get updates on the teams, players or events you care about most. SUN 11/231:00 PM Minnesota 4-6 70% +6½ -113BetRivers
Green Bay 6-3-1 30% -6½ -105Bet365
Personalize your notifications and get updates on the teams, players or events you care about most. SUN 11/231:00 PM Indianapolis 8-2 67% +3½ -114Caesars
Kansas City 5-5 33% -3 -121SugarHouse
Personalize your notifications and get updates on the teams, players or events you care about most. SUN 11/234:05 PM Jacksonville 6-4 45% -2½ -102Caesars
Arizona 3-7 55% +2½ -108BetRivers
Personalize your notifications and get updates on the teams, players or events you care about most. SUN 11/234:05 PM Cleveland 2-8 39% +3½ -109BetRivers
Las Vegas 2-8 61% -3½ -109Caesars
Personalize your notifications and get updates on the teams, players or events you care about most. SUN 11/234:25 PM Atlanta 3-7 24% +2 -115Caesars
New Orleans 2-8 76% +1 -115Bet365
Personalize your notifications and get updates on the teams, players or events you care about most. SUN 11/234:25 PM Philadelphia 8-2 62% -3 -105Bet365
Dallas 4-5-1 38% +3 -110Caesars
Personalize your notifications and get updates on the teams, players or events you care about most. SUN 11/238:20 PM Tampa Bay 6-4 46% +7 -105Bet365
L.A. Rams 8-2 54% -7 -105BetMGM
Personalize your notifications and get updates on the teams, players or events you care about most. MON 11/248:15 PM Carolina 6-5 86% +7½ -114Caesars
San Francisco 7-4 14% -7 -120Bet365
Personalize your notifications and get updates on the teams, players or events you care about most. FINALTHU 11/208:15 PM Buffalo 7-4 19 -4½ -110FanDuel
Houston 6-5 23 +5½ -115SugarHouse

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