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The upcoming NFL clash on November 30, 2025, between the Houston Texans and the Indianapolis Colts at Lucas Oil Stadium in Indianapolis, IN, promises an exciting Sunday football showdown. The Colts, favored by 4.5 points with a total of 44.5 points, have a strong home record of 6-0 SU and 4-2 ATS, making them a formidable opponent. Houston Texans, on the other hand, have a more modest away record of 2-3 SU and 1-4 ATS but have shown resilience in recent games.
Starting quarterbacks will be a key factor. The Colts are likely to start Daniel Jones, who is questionable but expected to play despite a fibula injury. The Texans will rely on C.J. Stroud, also questionable but practicing fully after a concussion. The Colts boast a stronger passing offense (245.18 yards/game) versus the Texans' pass defense (172.09 yards allowed), suggesting the Colts might have the edge through the air. Conversely, Houston's run offense (107.63 yards/game) slightly outperforms the Colts' run defense (97.36 yards allowed), highlighting a potential ground attack advantage for the Texans.
Defensively, the Colts have a solid pass rush with 3 sacks per game, matching the Texans' 3 sacks, but the Texans have been more effective in limiting passing yards. Both teams have some key injuries that could impact gameplay, including Houston's defensive end Darrell Taylor on IR and Colts' linebacker Daniel Scott on IR. The Colts have won 8 out of 11 games straight up this season, while Houston stands at 6-5.
Betting trends show the Colts as favorites at -4.5 with a total of 44.5 points. The Colts' strong home performance and better ATS record (7-4 overall, 4-2 at home) make them a solid pick. However, the Texans' recent win streak and ability to cover the spread in close games add intrigue. This game will be broadcast on CBS, making it accessible for fans and bettors alike. In their last matchup on October 27, 2024, the Texans edged the Colts 23-20, a reminder that this game could be tightly contested again.
These betting insights and game stats provide a solid foundation for making a smart wager. Ready to bet smarter? Start your OddsTrader Turbo subscription now or place your bet with a U.S. regulated sportsbook and profit off the edge.
Detroit 7-431% -2½ -120BetRivers | |||||||
Dallas 5-5-170% +3½ -112Caesars | |||||||
![]() Baltimore 6-522% -7 -110Bet365 | |||||||
Philadelphia 8-332% -7 -105Bet365 | |||||||
![]() Indianapolis 8-346% -3½ -110Bet365 | |||||||
![]() Tampa Bay 6-537% -2½ -110Bet365 | |||||||
![]() Tennessee 1-1076% +6½ -106FanDuel | |||||||
Carolina 6-651% +10½ -110Bet365 | |||||||
Miami 4-737% -5½ -113BetRivers | |||||||
![]() N.Y. Jets 2-973% +3 -125BetMGM | |||||||
Cleveland 3-822% +5½ -118BetMGM | |||||||
Seattle 8-367% -10½ -105FanDuel | |||||||
![]() Pittsburgh 6-583% +3½ -110BetMGM | |||||||
![]() L.A. Chargers 7-410% -9 -114SugarHouse | |||||||
![]() Washington 3-831% +6 -114BetRivers | |||||||
New England 10-215% -7 -118BetRivers |
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