Indianapolis Colts vs Jacksonville Jaguars Betting Trends

The upcoming NFL Week 14 game between the Jacksonville Jaguars and the Indianapolis Colts is set for December 7, 2025, at EverBank Stadium in Jacksonville, FL. This Sunday football matchup offers intriguing betting trends that bettors should not miss. Jacksonville enters the game with a strong home record of 4-2, while Indianapolis holds a solid away record of 2-3. The Colts, favored by 1.5 points with a total of 46 points, boast a more potent passing offense, averaging 241 yards per game, compared to Jacksonville's 203 yards. However, Jacksonville's defense is tough, allowing just 230 passing yards per game and maintaining a solid pass rush with 14 sacks. Quarterback Riley Leonard will start for Indianapolis, stepping in for the injured Anthony Richardson, who is on injured reserve, while Trevor Lawrence leads Jacksonville's offense.

Indianapolis has faced some setbacks with key injuries, including the absence of cornerbacks Sauce Gardner and Tyquan Lewis, which could impact their defensive stability. Jacksonville's injury report is lighter but includes the questionable status of safety Eric Murray and defensive end Travon Walker. The Colts' pass protection is crucial against a Jaguars pass rush that has recorded 14 sacks this season, while Jacksonville's pass offense will test the Colts' top-ranked pass defense, which allows only 230 passing yards per game.

Bettors should note the recent form: the Colts have lost three of their last five games outright but have a 7-5 ATS record, while the Jaguars have won four of their last five games outright and also hold a 7-5 ATS record. The total points line is set at 46, indicating a moderately high-scoring game. Given the Colts' strong pass defense and home-field advantage for Jacksonville, the betting trends suggest a close contest with the Colts favored to cover the spread.

This matchup is broadcast on CBS, providing fans and bettors with a great viewing experience. For those looking to dive deeper into game insights and make informed wagers, consider Start your OddsTrader Turbo subscription or place your bets with a U.S. regulated sportsbook.

In their last matchup on January 5, 2025, where the Colts edged the Jaguars 26-23, the Indianapolis Colts narrowly defeated Jacksonville, highlighting the competitive nature of this rivalry.