Jacksonville Jaguars vs Indianapolis Colts Betting Trends

The upcoming NFL showdown on December 28, 2025, features the Jacksonville Jaguars visiting the Indianapolis Colts at Lucas Oil Stadium in Indianapolis, IN. This Sunday football game is set to be an exciting contest, with the Jacksonville Jaguars entering as a strong favorite with a -6.5 point spread and the total points set at 48.5. The game will be broadcast on Fox, giving fans and bettors alike a prime viewing opportunity.

Jacksonville's offense, led by starting quarterback Trevor Lawrence, boasts a balanced attack with 218.3 passing yards and 29.1 rushing yards per game, while their defense allows 230.3 passing yards and 87.3 rushing yards on average. The Indianapolis Colts, starting with quarterback Daniel Jones, average 230.7 passing yards and 124.1 rushing yards per game offensively, but their defense struggles a bit more, giving up 250.7 passing and 98.5 rushing yards. This matchup pits Jacksonville's solid pass rush against Indianapolis' strong pass protection, a key factor for bettors to consider.

Jacksonville holds an impressive 11-4 straight-up record and is 10-5 ATS, showing strong consistency, especially on the road where they are 5-2 SU and 4-3 ATS. The Colts have a 8-7 SU and ATS record, with a solid 6-2 home record but only 4-4 ATS at home. Recent performances show Jacksonville winning their previous matchup against the Colts 36-19 on December 7, 2025, which may influence betting trends.

The point spread of -6.5 for Jacksonville indicates the bookmakers expect them to cover comfortably, but bettors should weigh the Colts' home advantage and recent defensive improvements. The total points line at 48.5 suggests a moderately high-scoring game, supported by both teams' offensive stats and recent games going over similar totals.

For the best betting edge, consider the Jaguars to cover the spread against the Colts. Ready to bet smarter? Start your OddsTrader Turbo subscription now or place your bet with a U.S. regulated sportsbook and profit off the edge. For odds comparison, the best lines today show the Colts at +6.5 -112 and Jaguars at -6.5 -109 at Caesars. Also, check out their last matchup on December 7, 2025, which Jacksonville won 36-19 for more context.