Dec 7, 2025 1:00 PM EST

Week 14

Indianapolis

8-4

Jacksonville

IND

-1½ (-110)o47½ (-110)

CBS

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Indianapolis Colts vs Jacksonville Jaguars Picks

Updated:Dec 4, 2025 1:21 AM EST

The upcoming NFL clash on December 7, 2025, between the Indianapolis Colts and Jacksonville Jaguars at EverBank Stadium in Jacksonville, FL promises an exciting Sunday football showdown. The game will be broadcasted on CBS, making it accessible for fans and bettors alike.

Our expert picks favor the Indianapolis Colts with a predicted score of 27 to 22, backing the Colts -1.5 spread. The total points are expected to be just over 47.5, with a predicted total score of 48.68. This prediction aligns with our profitable recent trends, where our model has had a 56.7% hit rate on the Colts spread bets and a 50.5% hit rate on over 47.5 totals, both showing positive expected value (EV).

Jacksonville Jaguars have shown strength recently, winning 6 of their last 10 games against the spread, but the Colts' home advantage and consistent performance make them the best bet in this matchup. Our predictions provide valuable betting tips to help you make informed wagers and boost your chances of winning. Explore more NFL picks and predictions on our NFL picks page to stay ahead of the game.

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Personalize your notifications and get updates on the teams, players or events you care about most. THU 12/048:15 PM Dallas 6-5-1 54% +3 -105Bet365
Detroit 7-5 46% -3 -110Caesars
Personalize your notifications and get updates on the teams, players or events you care about most. SUN 12/071:00 PM Washington 3-9 50% +2 -110Bet365
Minnesota 4-8 50% -1½ -112FanDuel
Personalize your notifications and get updates on the teams, players or events you care about most. SUN 12/071:00 PM Miami 5-7 28% -2½ -113Caesars
N.Y. Jets 3-9 72% +3 -118BetMGM
Personalize your notifications and get updates on the teams, players or events you care about most. SUN 12/071:00 PM Tennessee 1-11 90% +4 -109BetRivers
Cleveland 3-9 10% -3½ -122FanDuel
Personalize your notifications and get updates on the teams, players or events you care about most. SUN 12/071:00 PM Pittsburgh 6-6 66% +6 -110Bet365
Baltimore 6-6 34% -5½ -115FanDuel
Personalize your notifications and get updates on the teams, players or events you care about most. SUN 12/071:00 PM Seattle 9-3 16% -7 -105Bet365
Atlanta 4-8 84% +7 -108FanDuel
Personalize your notifications and get updates on the teams, players or events you care about most. SUN 12/071:00 PM Indianapolis 8-4 34% -1½ -110Bet365
Jacksonville 8-4 66% +1½ -107Caesars
Personalize your notifications and get updates on the teams, players or events you care about most. SUN 12/071:00 PM New Orleans 2-10 90% +8½ -108FanDuel
Tampa Bay 7-5 10% -8½ -110Bet365
Personalize your notifications and get updates on the teams, players or events you care about most. SUN 12/071:00 PM Cincinnati 4-8 64% +5½ -105FanDuel
Buffalo 8-4 36% -5½ -110Bet365
Personalize your notifications and get updates on the teams, players or events you care about most. SUN 12/074:05 PM Denver 10-2 16% -7½ -110Caesars
Las Vegas 2-10 84% +7½ -105BetMGM
Personalize your notifications and get updates on the teams, players or events you care about most. SUN 12/074:25 PM Chicago 9-3 47% +6½ -105Bet365
Green Bay 8-3-1 53% -6½ -110BetRivers
Personalize your notifications and get updates on the teams, players or events you care about most. SUN 12/074:25 PM L.A. Rams 9-3 10% -8 -110Caesars
Arizona 3-9 90% +8½ -114BetRivers
Personalize your notifications and get updates on the teams, players or events you care about most. SUN 12/078:20 PM Houston 7-5 73% +3½ -113Caesars
Kansas City 6-6 27% -3 -120Bet365
Personalize your notifications and get updates on the teams, players or events you care about most. MON 12/088:15 PM Philadelphia 8-4 28% -2½ -120Bet365
L.A. Chargers 8-4 72% +3 -110Caesars

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