Dec 7, 2025 1:00 PM EST

Week 14

Indianapolis

8-4

Jacksonville

IND

-1½ (-110)o46½ (-115)

CBS

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Indianapolis Colts vs Jacksonville Jaguars Picks

Updated:Dec 6, 2025 1:26 AM EST

The upcoming NFL matchup on December 7, 2025, features the Indianapolis Colts visiting the Jacksonville Jaguars at EverBank Stadium in Jacksonville, FL. This Sunday football game promises to be a thrilling contest as both teams vie for a crucial Week 14 victory. The Colts are favored to win with a predicted score of 26 to 22, and our picks lean towards the Colts covering the spread with a -2 point advantage. The total predicted score sits just under 48 points, suggesting a competitive but moderately high-scoring game.

Our prediction model has shown strength recently, boasting a solid hit rate of 54.9% on point spreads and an impressive 62.5% on moneyline bets for the Colts in similar matchups. Additionally, the over/under markets have been profitable, with the under 47.5 showing a positive track record. These betting tips can help you make smarter wagers by focusing on markets with higher expected value (EV) and cover percentages.

This game will be broadcast on CBS, allowing fans to catch all the action live. For bettors looking to dive deeper, you can explore more NFL picks and predictions on our dedicated NFL picks page. Ready to bet smarter? Start your OddsTrader Turbo subscription now or place your bet with a U.S. regulated sportsbook and profit off the edge.

Which team is favored to win according to the picks?

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ODDS PICKS PLAYER PROPS FUTURES PLAYER FUTURES INJURIES WEATHER RANKINGS STANDINGS

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Personalize your notifications and get updates on the teams, players or events you care about most. SUN 12/071:00 PM Washington 3-9 61% -1½ -108Caesars
Minnesota 4-8 39% +2 -115SugarHouse
Personalize your notifications and get updates on the teams, players or events you care about most. SUN 12/071:00 PM Miami 5-7 38% -3 +100Bet365
N.Y. Jets 3-9 62% +3 -114Caesars
Personalize your notifications and get updates on the teams, players or events you care about most. SUN 12/071:00 PM Tennessee 1-11 83% +4 -110Bet365
Cleveland 3-9 17% -3½ -114BetRivers
Personalize your notifications and get updates on the teams, players or events you care about most. SUN 12/071:00 PM Pittsburgh 6-6 67% +6 -110Bet365
Baltimore 6-6 33% -5½ -115FanDuel
Personalize your notifications and get updates on the teams, players or events you care about most. SUN 12/071:00 PM Seattle 9-3 18% -6½ -113Caesars
Atlanta 4-8 82% +7 -115BetMGM
Personalize your notifications and get updates on the teams, players or events you care about most. SUN 12/071:00 PM Indianapolis 8-4 42% -1½ -110Bet365
Jacksonville 8-4 58% +2 -115SugarHouse
Personalize your notifications and get updates on the teams, players or events you care about most. SUN 12/071:00 PM New Orleans 2-10 93% +8½ -110Bet365
Tampa Bay 7-5 7% -8 -117SugarHouse
Personalize your notifications and get updates on the teams, players or events you care about most. SUN 12/071:00 PM Cincinnati 4-8 49% +6 -110Bet365
Buffalo 8-4 51% -5½ -115BetRivers
Personalize your notifications and get updates on the teams, players or events you care about most. SUN 12/074:05 PM Denver 10-2 10% -7½ +100Bet365
Las Vegas 2-10 90% +7½ -110BetMGM
Personalize your notifications and get updates on the teams, players or events you care about most. SUN 12/074:25 PM Chicago 9-3 40% +6½ -105Caesars
Green Bay 8-3-1 60% -6½ -110BetRivers
Personalize your notifications and get updates on the teams, players or events you care about most. SUN 12/074:25 PM L.A. Rams 9-3 14% -8½ -105FanDuel
Arizona 3-9 86% +9 -112BetRivers
Personalize your notifications and get updates on the teams, players or events you care about most. SUN 12/078:20 PM Houston 7-5 69% +3½ -108FanDuel
Kansas City 6-6 31% -3 -121SugarHouse
Personalize your notifications and get updates on the teams, players or events you care about most. MON 12/088:15 PM Philadelphia 8-4 23% -2½ -110FanDuel
L.A. Chargers 8-4 77% +2½ -102Caesars
Personalize your notifications and get updates on the teams, players or events you care about most. FINALTHU 12/048:15 PM Dallas 6-6-1 30 +3½ -102BetMGM
Detroit 8-5 44 -3½ -102BetMGM

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