Betting Trends Indianapolis Colts vs Kansas City Chiefs

The upcoming NFL clash on November 23, 2025, between the Indianapolis Colts and Kansas City Chiefs at GEHA Field at Arrowhead Stadium in Kansas City, MO, promises an exciting Sunday football showdown. This game showcases a compelling quarterback matchup with the Colts likely starting Riley Leonard, while the Chiefs will feature Patrick Mahomes, a clear advantage for Kansas City given Mahomes' elite playmaking ability.

Analyzing the betting trends, the Chiefs are favored by 3.5 points with a total points line set at 50. The Colts have a solid 8-2 straight-up record and a 6-4 against-the-spread record, while the Chiefs hold a 5-5 straight-up and ATS record but boast a strong 4-1 home ATS record. The Colts' offense averages 251.6 passing yards and 145.3 rushing yards per game, while their defense allows 235.3 passing yards and 92.3 rushing yards. Conversely, the Chiefs' offense produces 248.9 passing yards and 115.3 rushing yards, with a defense conceding 196.8 passing yards and 100 rushing yards per game.

Key betting insights include the Colts' effective pass protection versus the Chiefs' pass rush, which could dictate the game's tempo. The Chiefs' defense is notably stingy against the pass, which may limit the Colts' aerial attack. Injury-wise, the Colts have some questionable players like Daniel Jones (QB) with a calf injury but are likely to play, while the Chiefs have a few questionables including Isiah Pacheco (RB) and Kingsley Suamataia (T), which could impact their offensive rhythm.

The Chiefs are -190 moneyline favorites at Caesars, with the Colts at +155. The point spread of -3.5 for the Chiefs reflects their home advantage and stronger recent defensive performances. The total points line at 50 suggests a moderately high-scoring game, but recent under trends for the Chiefs might temper expectations.

For bettors looking to capitalize on these betting trends and game insights, understanding the matchup nuances such as pass offense versus pass defense and run game dynamics is crucial. Ready to bet smarter? Start your OddsTrader Turbo subscription now or place your bet with a U.S. regulated sportsbook and profit off the edge. In their last matchup on September 25, 2022, where the Colts edged the Chiefs 20-17, the Colts showed they can compete tightly against Kansas City, adding intrigue to this Sunday football contest.