Nov 23, 2025 1:00 PM EST

Week 12

Indianapolis

5-5

Kansas City

-3½ (-106)o50 (-110)

CBS

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Indianapolis Colts vs Kansas City Chiefs Picks

Updated:Nov 21, 2025 1:47 AM EST

The upcoming NFL showdown on November 23, 2025, between the Indianapolis Colts and Kansas City Chiefs at GEHA Field at Arrowhead Stadium in Kansas City, MO, is one you won't want to miss. This Sunday football game will be broadcast on CBS, adding to the excitement for fans and bettors alike.

Our expert picks and betting tips highlight a predicted close contest with the Kansas City Chiefs favored to win 26-23 against the Indianapolis Colts. The Chiefs are predicted to cover the -3 spread, while the total points are expected to stay under 50.5, with a predicted total score of approximately 49 points. These insights come from a robust prediction model that has shown a profitable track record, particularly in the under total market, which has a high expected value (EV) and a strong hit rate over the last 10 games.

Considering the prediction results and coverage percentages, bettors can make informed decisions and potentially capitalize on the edge offered by these markets. For more detailed NFL picks and betting strategies, check out our comprehensive NFL picks page. Ready to bet smarter? Start your OddsTrader Turbo subscription now or place your wager with a U.S. regulated sportsbook and maximize your profits.

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ODDS PICKS PLAYER PROPS FUTURES PLAYER FUTURES INJURIES WEATHER RANKINGS STANDINGS

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Personalize your notifications and get updates on the teams, players or events you care about most. SUN 11/231:00 PM Pittsburgh 6-4 48% +3 -120BetRivers
Chicago 7-3 52% -2½ -114Caesars
Personalize your notifications and get updates on the teams, players or events you care about most. SUN 11/231:00 PM N.Y. Jets 2-8 85% +14 -115Bet365
Baltimore 5-5 15% -13 -115SugarHouse
Personalize your notifications and get updates on the teams, players or events you care about most. SUN 11/231:00 PM N.Y. Giants 2-9 93% +11 -118BetMGM
Detroit 6-4 7% -10½ -102FanDuel
Personalize your notifications and get updates on the teams, players or events you care about most. SUN 11/231:00 PM New England 9-2 33% -5½ -114FanDuel
Cincinnati 3-7 67% +7 -115Bet365
Personalize your notifications and get updates on the teams, players or events you care about most. SUN 11/231:00 PM Seattle 7-3 14% -12½ -110Bet365
Tennessee 1-9 86% +13½ -112FanDuel
Personalize your notifications and get updates on the teams, players or events you care about most. SUN 11/231:00 PM Minnesota 4-6 77% +6½ -110Caesars
Green Bay 6-3-1 23% -6½ -109Caesars
Personalize your notifications and get updates on the teams, players or events you care about most. SUN 11/231:00 PM Indianapolis 8-2 74% +3½ -114Caesars
Kansas City 5-5 26% -3 -120Bet365
Personalize your notifications and get updates on the teams, players or events you care about most. SUN 11/234:05 PM Jacksonville 6-4 40% -2½ -112FanDuel
Arizona 3-7 60% +3 -110Caesars
Personalize your notifications and get updates on the teams, players or events you care about most. SUN 11/234:05 PM Cleveland 2-8 43% +4 -110Bet365
Las Vegas 2-8 57% -3½ -118FanDuel
Personalize your notifications and get updates on the teams, players or events you care about most. SUN 11/234:25 PM Atlanta 3-7 33% +2½ -112Caesars
New Orleans 2-8 67% +1 -115Bet365
Personalize your notifications and get updates on the teams, players or events you care about most. SUN 11/234:25 PM Philadelphia 8-2 63% -3 -113Caesars
Dallas 4-5-1 37% +3½ -118BetRivers
Personalize your notifications and get updates on the teams, players or events you care about most. SUN 11/238:20 PM Tampa Bay 6-4 63% +7 -120BetRivers
L.A. Rams 8-2 37% -6½ -110Bet365
Personalize your notifications and get updates on the teams, players or events you care about most. MON 11/248:15 PM Carolina 6-5 87% +7 -105Bet365
San Francisco 7-4 13% -7 -110Caesars
Personalize your notifications and get updates on the teams, players or events you care about most. FINALTHU 11/208:15 PM Buffalo 7-4 19 -4½ -110FanDuel
Houston 6-5 23 +5½ -115SugarHouse

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