Dec 14, 2025 4:25 PM EST

Week 15

Indianapolis

10-3

Seattle

SEA

-13½ (-113)o42½ (-109)

CBS

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Indianapolis Colts vs Seattle Seahawks Picks

Updated:Dec 11, 2025 1:55 AM EST

The upcoming NFL regular season Week 15 game between the Indianapolis Colts and Seattle Seahawks on December 14, 2025, at Lumen Field in Seattle, WA, is generating significant buzz among football fans and bettors alike. This Sunday football matchup will be broadcasted on CBS, making it accessible for viewers nationwide. Our expert picks suggest a competitive game with the Seattle Seahawks favored to win 27-16 against the Indianapolis Colts, with a predicted point spread of Seattle -13.5. The total score is expected to hover around 42.8, indicating a moderately scoring game potentially going under 43.

Our betting tips are informed by a track record of success, with our prediction model boasting a strong hit rate in point spread markets, winning more than half of the last 10 games, especially in spreads with high expected value (EV). This consistent performance provides bettors with confidence when placing bets on this game. The Colts have shown resilience, but the Seahawks' home advantage at Lumen Field and their recent form make them the best bet for this Sunday football event.

For bettors looking to gain an edge, exploring the full range of NFL picks on our dedicated NFL picks page is highly recommended. Additionally, subscribing to OddsTrader Turbo offers advanced tools and insights to maximize betting profits. Ready to bet smarter? Start your OddsTrader Turbo subscription now or place your bet with a U.S. regulated sportsbook and profit off the edge.

When is the Indianapolis Colts vs Seattle Seahawks game?

NFL

ODDS PICKS PLAYER PROPS FUTURES PLAYER FUTURES INJURIES WEATHER RANKINGS STANDINGS

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Personalize your notifications and get updates on the teams, players or events you care about most. THU 12/118:15 PM Atlanta 4-9 59% +5 -118BetMGM
Tampa Bay 7-6 41% -4½ -110Caesars
Personalize your notifications and get updates on the teams, players or events you care about most. SUN 12/141:00 PM Arizona 3-10 82% +10 -110Bet365
Houston 8-5 18% -9 -114SugarHouse
Personalize your notifications and get updates on the teams, players or events you care about most. SUN 12/141:00 PM Las Vegas 2-11 85% +11½ -105FanDuel
Philadelphia 8-5 15% -10½ -115SugarHouse
Personalize your notifications and get updates on the teams, players or events you care about most. SUN 12/141:00 PM N.Y. Jets 3-10 71% +13½ -114Caesars
Jacksonville 9-4 29% -12½ -115SugarHouse
Personalize your notifications and get updates on the teams, players or events you care about most. SUN 12/141:00 PM Cleveland 3-10 87% +7½ -110Caesars
Chicago 9-4 13% -7½ -109BetRivers
Personalize your notifications and get updates on the teams, players or events you care about most. SUN 12/141:00 PM Buffalo 9-4 45% -1 -110Caesars
New England 11-2 55% +1½ -115FanDuel
Personalize your notifications and get updates on the teams, players or events you care about most. SUN 12/141:00 PM Baltimore 6-7 70% -2½ -110Bet365
Cincinnati 4-9 30% +2½ -105BetMGM
Personalize your notifications and get updates on the teams, players or events you care about most. SUN 12/141:00 PM L.A. Chargers 9-4 45% +6 -115BetRivers
Kansas City 6-7 55% -5½ -105FanDuel
Personalize your notifications and get updates on the teams, players or events you care about most. SUN 12/141:00 PM Washington 3-10 55% +2½ -105Bet365
N.Y. Giants 2-11 45% -2½ -110BetMGM
Personalize your notifications and get updates on the teams, players or events you care about most. SUN 12/144:25 PM Indianapolis 8-5 86% +14 -110Bet365
Seattle 10-3 14% -13½ -113Caesars
Personalize your notifications and get updates on the teams, players or events you care about most. SUN 12/144:25 PM Green Bay 9-3-1 72% -2 -110Bet365
Denver 11-2 28% +2½ -110BetMGM
Personalize your notifications and get updates on the teams, players or events you care about most. SUN 12/144:25 PM Carolina 7-6 38% -2½ -115Caesars
New Orleans 3-10 62% +3 -121SugarHouse
Personalize your notifications and get updates on the teams, players or events you care about most. SUN 12/144:25 PM Detroit 8-5 45% +6 -108Caesars
L.A. Rams 10-3 55% -5½ -114BetRivers
Personalize your notifications and get updates on the teams, players or events you care about most. SUN 12/144:25 PM Tennessee 2-11 96% +13 -114BetRivers
San Francisco 9-4 4% -12½ -110Bet365
Personalize your notifications and get updates on the teams, players or events you care about most. SUN 12/148:20 PM Minnesota 5-8 77% +6½ -115FanDuel
Dallas 6-6-1 23% -5½ -110Bet365
Personalize your notifications and get updates on the teams, players or events you care about most. MON 12/158:15 PM Miami 6-7 71% +3½ -110Bet365
Pittsburgh 7-6 29% -3½ -105BetMGM

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