San Francisco 49ers vs Philadelphia Eagles Betting Trends

The upcoming NFL clash on January 11, 2026, between the San Francisco 49ers and Philadelphia Eagles will take place at Lincoln Financial Field in Philadelphia, PA. This Sunday football game, broadcast on FOX, promises to be an exciting start to the PST Week 1 season.

The 49ers, led by starting quarterback Brock Purdy, face a tough Eagles defense that ranks high in pass defense and rush defense, making the passing game challenging. However, San Francisco's offense has been strong, averaging 25.71 points per game and 351.41 total yards, with a balanced attack of passing and rushing yards. The Eagles, starting Jalen Hurts at quarterback, bring a dynamic offense averaging 22.29 points and 311.24 total yards per game, with a solid pass protection against the 49ers' aggressive pass rush.

Betting trends show the Eagles favored by 4.5 points with a total points line at 45. The 49ers have a strong away ATS record of 7-2, while the Eagles hold a balanced home ATS record of 4-4. Past matchups, including the recent 42-19 Eagles win on December 3, 2023, indicate a competitive rivalry that bettors should watch closely. Key players like George Kittle (questionable) and Christian McCaffrey (full participation) for the 49ers, and A.J. Brown and DeVonta Smith for the Eagles, will influence the game's outcome.

Comparing pass offense to pass defense, the Eagles' defense is slightly more effective, whereas the 49ers excel in rushing offense against the Eagles' run defense. Pass protection for the Eagles is solid against a formidable 49ers pass rush, which could be a deciding factor in the game. These betting insights and game stats provide valuable information for making smart wagers. The best odds available today show the Eagles as favorites at -4.5 with Caesars sportsbook offering -109 odds.

For bettors looking to dive deeper, the last matchup on December 3, 2023, where the Eagles won 42-19 offers context on how these teams match up. Ready to bet smarter? Start your OddsTrader Turbo subscription now or place your bet with a U.S. regulated sportsbook and profit off the edge.