San Francisco 49ers vs Philadelphia Eagles Picks

The upcoming NFL clash on January 11, 2026, between the San Francisco 49ers and Philadelphia Eagles at Lincoln Financial Field in Philadelphia, PA, promises an exciting showdown for football fans and bettors alike. This Sunday football game will be broadcast on Fox, offering viewers a prime-time experience to enjoy the intensity and skill of both teams. Our expert picks suggest the Philadelphia Eagles will edge out the San Francisco 49ers with a predicted score of 25 to 23, favoring the Eagles at -4.5 on the point spread. This prediction is backed by a solid track record in our betting tips, with a high expected value (EV) of 8.6% on the San Francisco +4.5 spread and a cover percentage that reflects a strong hit rate.

Our prediction model has been profitable in recent games, particularly excelling in the American Total betting market, where the over 44.5 points option has shown a 55.3% coverage rate and a 4.1% EV, indicating favorable conditions for bettors. These insights help bettors make informed decisions by understanding market trends and leveraging profitable picks. For comprehensive analysis and more NFL picks, explore our detailed predictions on the NFL picks page. Additionally, bettors can find the best odds for this game at trusted sportsbooks like SugarHouse, ensuring a smart and enjoyable betting experience.