San Francisco 49ers vs Philadelphia Eagles Picks

The upcoming NFL showdown on January 11, 2026, features the San Francisco 49ers visiting the Philadelphia Eagles at Lincoln Financial Field in Philadelphia, PA. This Sunday football clash promises intense action and provides excellent betting opportunities for fans and bettors alike.

Our expert picks suggest a close game with the Philadelphia Eagles favored to win 25-22 against the San Francisco 49ers, with a predicted total score of around 47 points. The market shows a strong coverage percentage of 58.8% for Philadelphia in the 2-way market and 58.6% hit rate for San Francisco +6 on the point spread, indicating profitable betting tips for those considering the underdog spread.

Our prediction model has been profitable in recent games, especially in markets like the total score over/under and 2-way moneyline bets, with an impressive hit rate over the last 10 games. This data-driven approach helps bettors make smart decisions and capitalize on high expected value (EV) opportunities.

The game will be broadcast on FOX, giving fans a chance to watch the action live. For more in-depth NFL insights and picks, check out our comprehensive NFL picks and predictions page. Also, consider placing your bets through trusted platforms; the best odds are available today at SugarHouse sportsbook.