San Francisco 49ers vs Seattle Seahawks Betting Trends

The upcoming NFL showdown on January 17, 2026, features the San Francisco 49ers visiting the Seattle Seahawks at Lumen Field in Seattle, Washington. This Saturday football clash promises to be a thrilling contest broadcasted on Fox, offering bettors a prime opportunity to leverage the latest betting trends.

Seattle Seahawks, favored by 7.5 points with odds at -105, face the 49ers who are +7.5 underdogs at -115, with the total points set at 45. These odds reflect Seattle's strong home record of 6-2 and their impressive 14-3 overall season performance, ranking 3rd straight up and 2nd against the spread in the NFL standings. San Francisco counters with a solid 13-5 record and an 8-2 away ATS record, showcasing their resilience on the road.

Quarterback play is pivotal, with Seattle likely starting Sam Darnold, who is questionable but expected to participate, while San Francisco's Brock Purdy leads the offense. Seattle's pass offense averages 228 yards per game but faces a formidable 49ers pass defense allowing just 232 yards. Conversely, San Francisco's 244 passing yards per game will test Seattle's defense, which concedes 194 yards through the air. On the ground, Seattle's 123 rushing yards per game will challenge San Francisco's stout run defense allowing only 108 yards, making the run game a key betting insight.

Seattle's aggressive pass rush and San Francisco's solid pass protection will influence the quarterbacks' effectiveness. Recent games show Seattle's defense forcing turnovers and controlling the line of scrimmage. Fans can also revisit their recent encounter where Seattle defeated San Francisco 13-3 on January 3rd, a game that went under 48.5 points, providing valuable game stats for bettors.

With injuries affecting key players like San Francisco's Fred Warner (out) and Dee Winters (questionable), and Seattle's Sam Darnold (questionable), these factors could sway the game's outcome. Bettors looking for smart wagering should consider these betting trends and insights to make informed decisions. For the best odds today, check out BetOnline for Seattle and San Francisco wagers.