Seattle Seahawks vs San Francisco 49ers Betting Trends

The upcoming NFL Week 18 showdown on January 3, 2026, features the Seattle Seahawks vs San Francisco 49ers at Levi's Stadium in Santa Clara, CA. This Saturday football game is set to showcase a thrilling clash between two competitive teams with strong records. The Seahawks, currently boasting a 13-3 straight-up record and exceptional performance against the spread (11-5 overall, 7-1 away), face off against the 49ers who hold a solid 12-4 record and a commendable 11-5 ATS record at home. Seattle enters as the favorite with a -1 point spread and a total points line set at 49.5, indicating expectations of a high-scoring affair.

Quarterback-wise, the 49ers will rely on Brock Purdy as their starter, with George Kittle questionable but likely to play, adding to the offensive threat alongside Christian McCaffrey who is fully participating in practice. The Seahawks will start Sam Darnold, who is healthy and ready to challenge the 49ers defense. Both teams have shown strong offensive stats this season, with the 49ers averaging 362.56 total yards per game and Seattle close behind at 350.75. San Francisco's pass offense (252.31 yards per game) meets Seattle's pass defense (198.56 yards allowed per game), suggesting a tactical battle through the air. On the ground, Seattle's run offense (119.75 yards per game) faces a tough 49ers run defense (103.31 yards allowed per game), while pass protection and pass rush battles will be key in determining the game's pace.

Recent form favors the 49ers with impressive wins over the Chicago Bears and Indianapolis Colts, while the Seahawks have also been strong, winning against Carolina Panthers and Los Angeles Rams. The Seahawks' strong away ATS record and the 49ers' home ATS record provide critical betting insights for bettors. The Seahawks are -1 favorites at Caesars, with the total set at 49.5 points, suggesting a competitive and potentially high-scoring game. This matchup will be broadcast on ABC and ESPN, providing fans and bettors ample opportunity to catch all the action live.

For bettors looking to leverage these betting trends and game insights, this game offers a compelling opportunity. The strategic matchups in offense and defense, combined with the key players' performances and injury updates, make this a must-watch Saturday football event. Ready to bet smarter? Start your OddsTrader Turbo subscription now or place your bet with a U.S. regulated sportsbook and profit off the edge. In their last matchup on September 7, 2025, the 49ers edged the Seahawks 17-13, a close contest that sets the stage for this exciting rematch.