Dec 14, 2025 4:25 PM EST

Week 15

Tennessee

9-4

San Francisco

-12½ (-114)o44½ (-108)

FOX

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Tennessee Titans vs San Francisco 49ers Odds

Updated:Dec 10, 2025 1:42 AM EST

The highly anticipated NFL regular season game on December 14, 2025, between the Tennessee Titans and the San Francisco 49ers at Levi's Stadium in Santa Clara, CA, is shaping up to be a must-watch Sunday football event. The game kicks off at 4:25 PM and will be broadcast on Fox, providing fans with prime-time viewing. Bettors can find the latest odds and betting lines to make informed wagers on this exciting matchup.

Currently, the San Francisco 49ers are favored with a point spread of -12½ at -114 odds, while the Tennessee Titans are the underdogs at +12½ with -106 odds. The opening odds have remained relatively stable, indicating confidence in the 49ers' ability to cover the spread. The total points market is set at 44½, with the under favored at -112, suggesting a potentially defensive battle.

Understanding these odds and betting lines is crucial for bettors looking to gain an edge. The 49ers' strong home record at Levi's Stadium and their performance this season make them a compelling pick. Meanwhile, the Titans' resilience and potential to cover the spread offer value for underdog bettors. For those interested in more detailed analysis and up-to-the-minute odds, visiting the NFL odds page can provide additional insights.

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Personalize your notifications and get updates on the teams, players or events you care about most. THU 12/118:15 PM Atlanta 4-9 63% +5 -118BetMGM
Tampa Bay 7-6 37% -4 -110Bet365
Personalize your notifications and get updates on the teams, players or events you care about most. SUN 12/141:00 PM Arizona 3-10 83% +9½ -105BetMGM
Houston 8-5 17% -9½ -110Caesars
Personalize your notifications and get updates on the teams, players or events you care about most. SUN 12/141:00 PM Las Vegas 2-11 81% +11½ -115FanDuel
Philadelphia 8-5 19% -10½ -110Bet365
Personalize your notifications and get updates on the teams, players or events you care about most. SUN 12/141:00 PM N.Y. Jets 3-10 74% +12½ -110Bet365
Jacksonville 9-4 26% -11½ -112BetRivers
Personalize your notifications and get updates on the teams, players or events you care about most. SUN 12/141:00 PM Cleveland 3-10 93% +7½ -108FanDuel
Chicago 9-4 7% -7½ -110Caesars
Personalize your notifications and get updates on the teams, players or events you care about most. SUN 12/141:00 PM Buffalo 9-4 47% -1 -105Bet365
New England 11-2 53% +1½ -115FanDuel
Personalize your notifications and get updates on the teams, players or events you care about most. SUN 12/141:00 PM Baltimore 6-7 67% -2½ -110Bet365
Cincinnati 4-9 33% +2½ -105FanDuel
Personalize your notifications and get updates on the teams, players or events you care about most. SUN 12/141:00 PM L.A. Chargers 9-4 35% +4½ -108FanDuel
Kansas City 6-7 65% -4½ -110Bet365
Personalize your notifications and get updates on the teams, players or events you care about most. SUN 12/141:00 PM Washington 3-10 55% +2½ -112FanDuel
N.Y. Giants 2-11 45% -2 -110Bet365
Personalize your notifications and get updates on the teams, players or events you care about most. SUN 12/144:25 PM Indianapolis 8-5 89% +13½ -110Caesars
Seattle 10-3 11% -13½ -109Caesars
Personalize your notifications and get updates on the teams, players or events you care about most. SUN 12/144:25 PM Green Bay 9-3-1 82% -2 -114BetRivers
Denver 11-2 18% +2½ -110Caesars
Personalize your notifications and get updates on the teams, players or events you care about most. SUN 12/144:25 PM Carolina 7-6 45% -2½ -115Caesars
New Orleans 3-10 55% +3 -121SugarHouse
Personalize your notifications and get updates on the teams, players or events you care about most. SUN 12/144:25 PM Detroit 8-5 50% +5½ -105FanDuel
L.A. Rams 10-3 50% -5½ -110Bet365
Personalize your notifications and get updates on the teams, players or events you care about most. SUN 12/144:25 PM Tennessee 2-11 93% +12½ -106Caesars
San Francisco 9-4 7% -12½ -110Bet365
Personalize your notifications and get updates on the teams, players or events you care about most. SUN 12/148:20 PM Minnesota 5-8 70% +6½ -115FanDuel
Dallas 6-6-1 30% -5½ -110Bet365
Personalize your notifications and get updates on the teams, players or events you care about most. MON 12/158:15 PM Miami 6-7 65% +3½ -112Caesars
Pittsburgh 7-6 35% -3½ -105Bet365

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