Dec 14, 2025 4:25 PM EST

Week 15

Tennessee

9-4

San Francisco

-12½ (-110)o44½ (-112)

FOX

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Tennessee Titans vs San Francisco 49ers Odds

Updated:Dec 13, 2025 1:22 AM EST

The upcoming NFL showdown on December 14, 2025, between the Tennessee Titans and the San Francisco 49ers at Levi's Stadium in Santa Clara, CA, is set to be a thrilling Sunday football event. Fans and bettors alike will have the opportunity to watch this exciting game live on Fox, making it an unmissable occasion for NFL enthusiasts.

As the Titans prepare to visit the 49ers, the latest odds reveal the 49ers as favorites with a -12½ -110 point spread, while the Titans are the underdogs at +12½ -109. The opening odds showed a similar line, indicating steady confidence in the 49ers' advantage. The over/under totals are set at 44½, with the over priced at -112 and under at -108, reflecting expectations for a moderately high-scoring game.

Understanding these betting lines is crucial for making informed wagers. The point spread odds help bettors gauge the expected margin of victory, while the totals offer insight into the overall scoring potential of the matchup. Bettors can find the best odds available today for the 49ers at Caesars and for the Titans at the same sportsbook, ensuring competitive options for placing bets.

For those looking to enhance their betting strategy, start your OddsTrader Turbo subscription to access advanced tools and real-time odds updates. Additionally, keep an eye on the NFL odds page NFL odds page for the latest information on all league games.

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ODDS PICKS PLAYER PROPS FUTURES PLAYER FUTURES INJURIES WEATHER RANKINGS STANDINGS

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Personalize your notifications and get updates on the teams, players or events you care about most. SUN 12/141:00 PM Arizona 3-10 76% +9½ -105BetMGM
Houston 8-5 24% -9 -113BetRivers
Personalize your notifications and get updates on the teams, players or events you care about most. SUN 12/141:00 PM Las Vegas 2-11 91% +12½ -110Bet365
Philadelphia 8-5 9% -11½ -120FanDuel
Personalize your notifications and get updates on the teams, players or events you care about most. SUN 12/141:00 PM N.Y. Jets 3-10 72% +13½ -110BetMGM
Jacksonville 9-4 28% -13 -115Bet365
Personalize your notifications and get updates on the teams, players or events you care about most. SUN 12/141:00 PM Cleveland 3-10 78% +7½ -110Caesars
Chicago 9-4 22% -7½ -109BetRivers
Personalize your notifications and get updates on the teams, players or events you care about most. SUN 12/141:00 PM Buffalo 9-4 45% -1 -110Bet365
New England 11-2 55% +1½ -114Caesars
Personalize your notifications and get updates on the teams, players or events you care about most. SUN 12/141:00 PM Baltimore 6-7 45% -2½ -114Caesars
Cincinnati 4-9 55% +2½ -102FanDuel
Personalize your notifications and get updates on the teams, players or events you care about most. SUN 12/141:00 PM L.A. Chargers 9-4 65% +5½ -108Caesars
Kansas City 6-7 35% -5½ -110Bet365
Personalize your notifications and get updates on the teams, players or events you care about most. SUN 12/141:00 PM Washington 3-10 71% +2½ -105Bet365
N.Y. Giants 2-11 29% -2½ -112Caesars
Personalize your notifications and get updates on the teams, players or events you care about most. SUN 12/144:25 PM Indianapolis 8-5 58% +14 -114BetRivers
Seattle 10-3 42% -13½ -115Bet365
Personalize your notifications and get updates on the teams, players or events you care about most. SUN 12/144:25 PM Green Bay 9-3-1 76% -2 -110Bet365
Denver 11-2 24% +2½ -110BetMGM
Personalize your notifications and get updates on the teams, players or events you care about most. SUN 12/144:25 PM Carolina 7-6 29% -2½ -120Caesars
New Orleans 3-10 71% +3 -117BetRivers
Personalize your notifications and get updates on the teams, players or events you care about most. SUN 12/144:25 PM Detroit 8-5 40% +6 -107Caesars
L.A. Rams 10-3 60% -5½ -117SugarHouse
Personalize your notifications and get updates on the teams, players or events you care about most. SUN 12/144:25 PM Tennessee 2-11 89% +12½ -106FanDuel
San Francisco 9-4 11% -12 -115SugarHouse
Personalize your notifications and get updates on the teams, players or events you care about most. SUN 12/148:20 PM Minnesota 5-8 70% +6½ -115FanDuel
Dallas 6-6-1 30% -5 -118BetMGM
Personalize your notifications and get updates on the teams, players or events you care about most. MON 12/158:15 PM Miami 6-7 64% +3 -105Bet365
Pittsburgh 7-6 36% -3 -113Caesars
Personalize your notifications and get updates on the teams, players or events you care about most. FINALTHU 12/118:15 PM Atlanta 5-9 29 +6 -110Caesars
Tampa Bay 7-7 28 -5½ -112SugarHouse

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