Dec 14, 2025 4:25 PM EST

Week 15

Tennessee

9-4

San Francisco

-12½ (-110)o44½ (-112)

FOX

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Tennessee Titans vs San Francisco 49ers Odds

Updated:Dec 12, 2025 1:28 AM EST

The upcoming NFL showdown on December 14, 2025, features the Tennessee Titans vs San Francisco 49ers at Levi's Stadium in Santa Clara, CA. This Sunday football game promises to be a thrilling contest as the 49ers host the Titans in Week 15 of the 2025-26 season. Broadcast on FOX, fans and bettors alike will have plenty to watch and wager on.

Current odds favor the San Francisco 49ers as strong favorites with a point spread of -12½ -110, compared to the Tennessee Titans at +12½ -109, both offered by Caesars sportsbook. The opening odds showed the same spread but a slight adjustment in price indicates some movement in betting lines, signaling shifting bettor confidence. The total points market is set at 44½ with the over at -112 and the under at -108, providing additional options for betting enthusiasts.

Understanding these odds and betting lines is crucial for making informed wagers. The significant point spread suggests that the 49ers are expected to dominate, but underdog bettors might find value on the Titans' side. Bettors can leverage this data to strategize their bets effectively.

For comprehensive insights and to place your bets, visit the NFL odds page for all the latest updates. Ready to bet smarter? Start your OddsTrader Turbo subscription now or place your bet with a U.S. regulated sportsbook to capitalize on this exciting NFL matchup.

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ODDS PICKS PLAYER PROPS FUTURES PLAYER FUTURES INJURIES WEATHER RANKINGS STANDINGS

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Personalize your notifications and get updates on the teams, players or events you care about most. SUN 12/141:00 PM Arizona 3-10 78% +9½ -105BetMGM
Houston 8-5 22% -9 -113BetRivers
Personalize your notifications and get updates on the teams, players or events you care about most. SUN 12/141:00 PM Las Vegas 2-11 93% +12 -114BetRivers
Philadelphia 8-5 7% -11½ -110Bet365
Personalize your notifications and get updates on the teams, players or events you care about most. SUN 12/141:00 PM N.Y. Jets 3-10 74% +13½ -114Caesars
Jacksonville 9-4 26% -12½ -115SugarHouse
Personalize your notifications and get updates on the teams, players or events you care about most. SUN 12/141:00 PM Cleveland 3-10 84% +7½ -110Caesars
Chicago 9-4 16% -7½ -110Caesars
Personalize your notifications and get updates on the teams, players or events you care about most. SUN 12/141:00 PM Buffalo 9-4 45% -1 -110Caesars
New England 11-2 55% +1½ -114BetRivers
Personalize your notifications and get updates on the teams, players or events you care about most. SUN 12/141:00 PM Baltimore 6-7 41% -2½ -114Caesars
Cincinnati 4-9 59% +3 -124SugarHouse
Personalize your notifications and get updates on the teams, players or events you care about most. SUN 12/141:00 PM L.A. Chargers 9-4 74% +5½ -108Caesars
Kansas City 6-7 26% -5½ -110Bet365
Personalize your notifications and get updates on the teams, players or events you care about most. SUN 12/141:00 PM Washington 3-10 73% +2½ -105Bet365
N.Y. Giants 2-11 27% -2½ -110BetRivers
Personalize your notifications and get updates on the teams, players or events you care about most. SUN 12/144:25 PM Indianapolis 8-5 53% +14 -113BetRivers
Seattle 10-3 47% -13½ -115Bet365
Personalize your notifications and get updates on the teams, players or events you care about most. SUN 12/144:25 PM Green Bay 9-3-1 82% -2 -110Bet365
Denver 11-2 18% +2½ -110BetMGM
Personalize your notifications and get updates on the teams, players or events you care about most. SUN 12/144:25 PM Carolina 7-6 33% -2½ -120Caesars
New Orleans 3-10 67% +3 -120BetRivers
Personalize your notifications and get updates on the teams, players or events you care about most. SUN 12/144:25 PM Detroit 8-5 39% +6 -102Caesars
L.A. Rams 10-3 61% -5½ -118FanDuel
Personalize your notifications and get updates on the teams, players or events you care about most. SUN 12/144:25 PM Tennessee 2-11 92% +12½ -105BetMGM
San Francisco 9-4 8% -12 -112BetRivers
Personalize your notifications and get updates on the teams, players or events you care about most. SUN 12/148:20 PM Minnesota 5-8 73% +6½ -115FanDuel
Dallas 6-6-1 27% -5½ -110Bet365
Personalize your notifications and get updates on the teams, players or events you care about most. MON 12/158:15 PM Miami 6-7 65% +3 -105Bet365
Pittsburgh 7-6 35% -3 -113Caesars
Personalize your notifications and get updates on the teams, players or events you care about most. FINALTHU 12/118:15 PM Atlanta 5-9 29 +6 -110Caesars
Tampa Bay 7-7 28 -5½ -112SugarHouse

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