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FINAL
Dec 14, 2025 4:25 PM EST
TEN 24 vs SF 37
Week 15
SF
-12½ (-110)o45 (-110)
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Tennessee Titans vs San Francisco 49ers Odds
Updated:Dec 14, 2025 1:38 AM EST
The upcoming NFL clash on December 14, 2025, between the Tennessee Titans and the San Francisco 49ers at Levi's Stadium in Santa Clara, CA, is set to be a thrilling Sunday football showdown. This Week 15 regular-season game promises high stakes as the 49ers look to defend their home turf against the Titans.
Current odds favor the San Francisco 49ers as the favorites at -12½ -110, with the Tennessee Titans as the underdogs at +12½ -109 according to Caesars sportsbook. The opening odds were slightly different, indicating a shift in betting lines that savvy bettors should note. Understanding these odds movements can provide valuable insights into where the money is flowing and help bettors make informed decisions.
The over/under total is set at 44½ with the under slightly favored at -112. Bettors can leverage these betting odds to gauge the expected pace and scoring of the game. This matchup will be broadcast on FOX, making it accessible for fans and bettors alike.
For those looking to dive deeper into the NFL betting landscape, check out our comprehensive NFL odds page. Ready to bet smarter? Start your OddsTrader Turbo subscription now or place your bet with a U.S. regulated sportsbook and profit off the edge.
Spread (FULL GAME)
COVER PROB.EXPECTED VALUEBEST LINE
TennesseeSpread
+4.1%
EV
+4.1%
San FranciscoSpread
-6.4%
EV
-6.4%
MONEYLINE (FULL GAME)
COVER PROB.EXPECTED VALUEBEST LINE
TennesseeMONEYLINE
+5.0%
EV
+5.0%
San FranciscoMONEYLINE
-8.0%
EV
-8.0%
Total (FULL GAME)
COVER PROB.EXPECTED VALUEBEST LINE
OVERTotal
-2.2%
EV
-2.2%
UNDERTotal
-3.9%
EV
-3.9%
Spread (1H)
BEST LINE
TennesseeSpread
San FranciscoSpread
MONEYLINE (1H)
BEST LINE
TennesseeMONEYLINE
San FranciscoMONEYLINE
Total (1H)
BEST LINE
OVERTotal
UNDERTotal
Spread (2H)
BEST LINE
TennesseeSpread
San FranciscoSpread
MONEYLINE (2H)
BEST LINE
TennesseeMONEYLINE
San FranciscoMONEYLINE
DRAWMONEYLINE
Total (2H)
BEST LINE
OVERTotal
UNDERTotal
Spread (1Q)
BEST LINE
TennesseeSpread
San FranciscoSpread
MONEYLINE (1Q)
BEST LINE
TennesseeMONEYLINE
San FranciscoMONEYLINE
Total (1Q)
BEST LINE
OVERTotal
UNDERTotal
Spread (2Q)
BEST LINE
TennesseeSpread
San FranciscoSpread
MONEYLINE (2Q)
BEST LINE
TennesseeMONEYLINE
San FranciscoMONEYLINE
Total (2Q)
BEST LINE
OVERTotal
UNDERTotal
Spread (3Q)
BEST LINE
TennesseeSpread
San FranciscoSpread
MONEYLINE (3Q)
BEST LINE
TennesseeMONEYLINE
San FranciscoMONEYLINE
Total (3Q)
BEST LINE
OVERTotal
UNDERTotal
Spread (4Q)
BEST LINE
TennesseeSpread
San FranciscoSpread
MONEYLINE (4Q)
BEST LINE
TennesseeMONEYLINE
San FranciscoMONEYLINE
Total (4Q)
BEST LINE
OVERTotal
UNDERTotal
NFL
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NFLWeek 15
 Pittsburgh 7-638% -3 -113Caesars | |||||||
 Tampa Bay 7-728 -5½ -112SugarHouse | |||||||
 Houston 9-540 -10 -110Bet365 | |||||||
 Philadelphia 9-531 -12 -118BetMGM | |||||||
 Jacksonville 10-448 -13½ -110Bet365 | |||||||
 Chicago 10-431 -7½ -107Caesars | |||||||
 New England 11-331 +2½ -110Bet365 | |||||||
 Cincinnati 4-100 +3 -106FanDuel | |||||||
 Kansas City 6-813 -5½ -118SugarHouse | |||||||
 N.Y. Giants 2-1221 -2½ -115Caesars | |||||||
 Seattle 11-318 -13 -105Bet365 | |||||||
 Denver 12-234 +1½ -112FanDuel | |||||||
 New Orleans 4-1020 +2½ -105BetMGM | |||||||
 L.A. Rams 11-341 -5½ -114BetRivers | |||||||
 San Francisco 10-437 -11½ -118BetMGM | |||||||
 Dallas 6-7-126 -4½ -110FanDuel |
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