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The upcoming NFL regular season clash on December 14, 2025, between the San Francisco 49ers and the Tennessee Titans at Levi's Stadium in Santa Clara, CA, promises an exciting Sunday football showdown. This game features a compelling matchup of pass offense versus pass defense and run offense against run defense, which will significantly impact game props and betting strategies. The 49ers' outdoor venue and home advantage add an extra layer of intrigue to this contest.
The San Francisco 49ers and Tennessee Titans both bring unique strengths that bettors should consider. The 49ers' pass protection will be tested against the Titans' aggressive pass rush, affecting the flow of the game and potential scoring opportunities, including touchdowns and field goals. Our projections highlight that the player to score the first touchdown market has shown a high hit rate and EV in recent games, making it a prime prop bet to watch.
Our prop bets and team props have performed well in the last 10 games, providing valuable insights for bettors looking to capitalize on game projections and totals. The Tennessee Titans versus San Francisco 49ers game will be broadcast on FOX, giving fans a chance to watch the action live. For those ready to bet smarter, Start your OddsTrader Turbo subscription or place your wager with a U.S. regulated sportsbook and gain an edge with expert insights.
![]() Pittsburgh 7-638% -3 -113Caesars | |||||||
![]() Tampa Bay 7-728 -5½ -112SugarHouse | |||||||
![]() Houston 9-540 -10 -110Bet365 | |||||||
Philadelphia 9-531 -12 -118BetMGM | |||||||
Jacksonville 10-448 -13½ -110Bet365 | |||||||
![]() Chicago 10-431 -7½ -107Caesars | |||||||
New England 11-331 +2½ -110Bet365 | |||||||
![]() Cincinnati 4-100 +3 -106FanDuel | |||||||
![]() Kansas City 6-813 -5½ -118SugarHouse | |||||||
![]() N.Y. Giants 2-1221 -2½ -115Caesars | |||||||
Seattle 11-318 -13 -105Bet365 | |||||||
Denver 12-234 +1½ -112FanDuel | |||||||
New Orleans 4-1020 +2½ -105BetMGM | |||||||
![]() L.A. Rams 11-341 -5½ -114BetRivers | |||||||
![]() San Francisco 10-437 -11½ -118BetMGM | |||||||
Dallas 6-7-126 -4½ -110FanDuel |
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