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FINAL
Dec 21, 2025 4:05 PM EST
ATL 26 vs ARI 19
Week 16
ATL
-2½ (-115)o48½ (-105)
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Atlanta Falcons vs Arizona Cardinals Odds Week 16
Updated:Dec 21, 2025 1:14 AM EST
The upcoming NFL matchup on December 21, 2025, features the Atlanta Falcons taking on the Arizona Cardinals at State Farm Stadium in Glendale, AZ. This Week 16 game promises to be a thrilling contest as both teams vie for a crucial win in the 2025-26 NFL season. Fans and bettors alike will want to tune in to FOX for full coverage of this Sunday football showdown. Current odds favor the Atlanta Falcons as favorites with a point spread of -3½ -107, compared to the opening spread of -3 -110, indicating a slight shift in betting lines towards the Falcons. The over/under total stands at 48½, with the under favored at -113. These betting odds provide valuable insights for bettors considering their wagers, highlighting the Falcons' slight edge but also the potential for a close game. Arizona Cardinals vs Atlanta Falcons betting lines have evolved since the opening, reflecting market confidence and team performance trends. Bettors should consider these movements carefully to make informed decisions. For those wanting to dive deeper into the NFL betting landscape, our comprehensive NFL odds page offers all the latest odds and updates. Ready to bet smarter? Start your OddsTrader Turbo subscription now or place your bet with a U.S. regulated sportsbook and profit off the edge. The best odds available today for the Falcons are -3½ -107 at Caesars, while the Cardinals can be backed at +3 +113 at the same sportsbook. Use these insights to enhance your betting strategy and enjoy a more thrilling NFL experience.
Spread (FULL GAME)
COVER PROB.EXPECTED VALUEBEST LINE
AtlantaSpread
+3.4%
EV
+3.4%
ArizonaSpread
-8.4%
EV
-8.4%
MONEYLINE (FULL GAME)
COVER PROB.EXPECTED VALUEBEST LINE
AtlantaMONEYLINE
+4.9%
EV
+4.9%
ArizonaMONEYLINE
-10.1%
EV
-10.1%
Total (FULL GAME)
COVER PROB.EXPECTED VALUEBEST LINE
OVERTotal
-6.6%
EV
-6.6%
UNDERTotal
+2.0%
EV
+2.0%
Spread (1H)
BEST LINE
AtlantaSpread
ArizonaSpread
MONEYLINE (1H)
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AtlantaMONEYLINE
ArizonaMONEYLINE
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ArizonaSpread
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OVERTotal
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AtlantaSpread
ArizonaSpread
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AtlantaMONEYLINE
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OVERTotal
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AtlantaSpread
ArizonaSpread
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AtlantaMONEYLINE
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OVERTotal
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Spread (4Q)
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AtlantaSpread
ArizonaSpread
MONEYLINE (4Q)
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AtlantaMONEYLINE
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NFL
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NFLWeek 1
 Seattle - -3½ -110BetOnline | |||||||
.png?d=100x100) L.A. Rams - -3 -120Bovada | |||||||
 Jacksonville - -7½ -101Bet105 | |||||||
 Cincinnati - -3½ -102Bet105 | |||||||
 Indianapolis - +3½ -110BetOnline | |||||||
 Pittsburgh - -2½ -122Bet105 | |||||||
 Houston - +1½ -120Bovada | |||||||
 Carolina - +2½ -102Bet105 | |||||||
 Tennessee - -2½ -110Bookmaker | |||||||
 Detroit - -7 -105Bet105 | |||||||
 L.A. Chargers - -10 -115Bookmaker | |||||||
 Las Vegas - -3 -120BetOnline | |||||||
 Philadelphia - -4 -103Bet105 | |||||||
 Minnesota - +1½ -115Bovada | |||||||
 N.Y. Giants - +3 -110MyBookie | |||||||
 Kansas City - -2½ -110MyBookie |
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