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The Arizona Cardinals face off against the Buffalo Bills at Highmark Stadium in Orchard Park, NY, on September 8, 2024, at 1:00 PM EDT. The game will be broadcast live on CBS. This Week 1 matchup is set to be an exciting clash between two strong teams. The Bills come into the game as 6.5-point favorites with odds of -115, while the Cardinals are +6.5 underdogs with odds of -105. In their last matchup on November 15, 2020, the Cardinals narrowly defeated the Bills 32-30. Key players to watch include Buffalo's starting quarterback Josh Allen and Arizona's quarterback Kyler Murray. Both teams have shown strong offensive capabilities, with the Bills scoring an average of 34 points per game and the Cardinals 28 points. For more details on their ATS records, check out our NFL standings page. The game promises high stakes and is crucial for both teams' season start. Betting enthusiasts should note the spread and total points, which stand at 45.5. This game is a must-watch for football fans and bettors alike.