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Get ready for an exciting NFL matchup between the Tennessee Titans and the Arizona Cardinals on October 5, 2025, at State Farm Stadium in Glendale, AZ. With the Cardinals being the favorites at -7½ -110, bettors are eyeing the point spread closely. The Titans, however, are looking to upset the odds with a +7½ -110 line. This game, broadcasted on CBS, promises thrilling Sunday football action. The opening odds had the Cardinals at a -6½ spread, indicating a shift in favor of Arizona, reflecting the bettors' confidence. This shift could be due to recent performances and injuries. As the game nears, the over/under is set at 41 points, with a slight favor towards the over at o41 -115. For those looking to place smart bets, consider the Cardinals' strong home record and the Titans' recent defensive struggles. For more detailed odds and insights, visit our NFL odds page. Whether you're a seasoned bettor or a newbie, Start your OddsTrader Turbo subscription now for an edge in your betting strategy.