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The upcoming clash on September 22, 2025, between the Detroit Lions and Baltimore Ravens at M&T Bank Stadium in Baltimore, MD, promises to be a thrilling Monday night football matchup. Both teams are coming off intense games, and fans can catch the action live on ABC/ESPN. The Ravens have been strong at home, but the Lions are determined to make an impact. Our prediction model gives the Ravens a slight edge with a predicted score of 26-24, favoring Baltimore by 4.5 points. However, the Lions' ability to cover a +5.5 spread with a 57.5% hit rate makes them a tempting bet. Our model has been profitable in the last 10 games, especially in the 2way market, winning 7 of them. With a predicted total score of 49.821, the under 54 market presents a high EV. Ready to bet smarter? Start your OddsTrader Turbo subscription now or place your bet with a U.S. regulated sportsbook and profit off the edge. For more insights, check our NFL picks page.