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The upcoming game between the Buffalo Bills and the Chicago Bears promises to be an exciting clash as both teams gear up for the 2025-26 NFL season. Our predictions indicate a close match, with the Buffalo Bills slightly favored to win. Based on our analysis, the predicted score is Buffalo Bills 24, Chicago Bears 21. We recommend betting on the Buffalo Bills to cover the spread, given their solid performance metrics in recent games. For more detailed insights, you can visit our NFL picks page.