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FINAL
Dec 21, 2025 1:00 PM EST
BUF 23 vs CLE 20
Week 16
BUF
-10½ (-110)o41 (-115)
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Buffalo Bills vs Cleveland Browns Odds
Updated:Dec 21, 2025 1:17 AM EST
The upcoming NFL showdown on December 21, 2025, between the Cleveland Browns and Buffalo Bills at Huntington Bank Field in Cleveland, OH, is set to be a thrilling contest. This Sunday football game will be broadcasted on CBS, drawing fans eager to see these two teams battle it out in Week 16 of the NFL season.
The latest odds favor the Buffalo Bills as the favorites with a point spread of -10½ -107, while the Cleveland Browns are the underdogs at +10½ -114 according to Caesars sportsbook. The opening point spread was the same, indicating steady confidence in the Bills' advantage. The total points line is set at 41½ with the over priced at -110. These betting lines provide valuable insights that bettors can use to make informed decisions on where to place their wagers.
Understanding the betting odds and point spread is crucial for bettors aiming to capitalize on this game. The Browns will look to leverage their home-field advantage at Huntington Bank Field, but the Bills have shown strong performances this season. For those interested in more detailed NFL betting odds and trends, visit the NFL odds page. Ready to bet smarter? Start your OddsTrader Turbo subscription now or place your bet with a U.S. regulated sportsbook and profit off the edge.
Spread (FULL GAME)
COVER PROB.EXPECTED VALUEBEST LINE
BuffaloSpread
+5.2%
EV
+5.2%
ClevelandSpread
-7.6%
EV
-7.6%
MONEYLINE (FULL GAME)
COVER PROB.EXPECTED VALUEBEST LINE
BuffaloMONEYLINE
+7.6%
EV
+7.6%
ClevelandMONEYLINE
-10.6%
EV
-10.6%
Total (FULL GAME)
COVER PROB.EXPECTED VALUEBEST LINE
OVERTotal
-6.4%
EV
-6.4%
UNDERTotal
+2.4%
EV
+2.4%
Spread (1H)
BEST LINE
BuffaloSpread
ClevelandSpread
MONEYLINE (1H)
BEST LINE
BuffaloMONEYLINE
ClevelandMONEYLINE
Total (1H)
BEST LINE
OVERTotal
UNDERTotal
Spread (2H)
BEST LINE
BuffaloSpread
ClevelandSpread
MONEYLINE (2H)
BEST LINE
BuffaloMONEYLINE
ClevelandMONEYLINE
Total (2H)
BEST LINE
OVERTotal
UNDERTotal
Spread (1Q)
BEST LINE
BuffaloSpread
ClevelandSpread
MONEYLINE (1Q)
BEST LINE
BuffaloMONEYLINE
ClevelandMONEYLINE
Total (1Q)
BEST LINE
OVERTotal
UNDERTotal
Spread (2Q)
BEST LINE
BuffaloSpread
ClevelandSpread
MONEYLINE (2Q)
BEST LINE
BuffaloMONEYLINE
ClevelandMONEYLINE
Total (2Q)
BEST LINE
OVERTotal
UNDERTotal
Spread (3Q)
BEST LINE
BuffaloSpread
ClevelandSpread
MONEYLINE (3Q)
BEST LINE
BuffaloMONEYLINE
ClevelandMONEYLINE
Total (3Q)
BEST LINE
OVERTotal
UNDERTotal
Spread (4Q)
BEST LINE
BuffaloSpread
ClevelandSpread
MONEYLINE (4Q)
BEST LINE
BuffaloMONEYLINE
ClevelandMONEYLINE
Total (4Q)
BEST LINE
OVERTotal
UNDERTotal
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