Miami Dolphins vs Buffalo Bills Betting Trends

The Miami Dolphins are set to challenge the Buffalo Bills on September 18, 2025, in a thrilling Thursday night football encounter at Highmark Stadium in Orchard Park, NY. This game, airing on Amazon Prime Video, promises to be a captivating clash. The Dolphins' offense, led by quarterback Tua Tagovailoa, will face a formidable Bills defense. Buffalo's Josh Allen, known for his dynamic play, will lead the charge against Miami's defense, which has shown vulnerabilities in recent performances.

The Bills are favored with a -11.5 point spread, and the total points over/under is set at 49.5. Buffalo's pass offense, averaging 284 passing yards per game, will test Miami's pass defense, which has allowed an average of 236.5 passing yards. Meanwhile, Miami's run game, with only 69.5 rushing yards on average, will face Buffalo's strong run defense.

Buffalo's recent form has been impressive, boasting a 2-0 record against the spread, a fact that bettors can explore further on our NFL standings page. Miami, however, is struggling with a 0-2 record. In their last matchup, Buffalo edged Miami 30-27. Bettors eyeing this matchup should consider these betting trends and game insights to make informed decisions. Ready to bet smarter? Start your OddsTrader Turbo subscription now or place your bet with a U.S. regulated sportsbook.