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FINAL
Dec 14, 2025 1:00 PM EST
BUF 35 vs NE 31
Week 15
BUF
-2½ (-113)o49½ (-110)
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Buffalo Bills vs New England Patriots Picks
Updated:Dec 13, 2025 1:31 AM EST
The upcoming NFL matchup on December 14, 2025, features the Buffalo Bills vs New England Patriots at Gillette Stadium in Foxborough, MA. This Sunday football game is set to be broadcast on CBS, bringing fans and bettors an exciting opportunity to engage with the league's top action. Our expert picks and betting tips highlight the Bills as slight favorites with a predicted score of 27 to 22 over the Patriots, with the Bills favored by 1 point on the spread.
Our prediction model has been profitable in recent games, boasting a solid hit rate of 62.5% on 2-way bets and a 57.2% hit rate on point spreads, which gives bettors confidence in the Buffalo Bills' edge in this contest. The model also suggests the total score will hover near the 49.5 mark, with a slight lean towards the under at 50.1% coverage, indicating a potentially tight defensive battle.
This game at Gillette Stadium is a perfect chance to leverage our NFL picks and predictions to make smart betting decisions. Whether you are placing straight bets or exploring parlays, the data and insights we provide can give you a profitable edge. For more in-depth NFL betting advice, check out our comprehensive NFL picks and predictions. Ready to bet smarter? Start your OddsTrader Turbo subscription now or place your bet with a U.S. regulated sportsbook and profit off the edge.
UPCOMING GAME PREDICTION
Spread
Money
Total
BUFSpread
CONSENSUS LINE
-2½ (-109)
PROJECTION
NE (22) - BUF (28)
COVER PROBABILITY
EXPECTED VALUE
+3.8%
BET RATING
SEASON COVER %
6/13
46%
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