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FINAL
Sep 28, 2025 1:00 PM EDT
NO 19 vs BUF 31
Week 4
BUF
-14½ (-105)o49 (-107)
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New Orleans Saints vs Buffalo Bills Odds
Updated:Sep 28, 2025 3:44 AM EDT
Get ready for a thrilling NFL showdown as the New Orleans Saints take on the Buffalo Bills on September 28, 2025, at Highmark Stadium in Orchard Park, NY. This clash promises to be a nail-biter as the Bills, led by their dynamic offense, face off against the Saints' resilient defense. Both teams are eager to secure a win in this early season matchup.
The current odds favor the Buffalo Bills with a -1½ -107 point spread at Caesars. Meanwhile, the New Orleans Saints are looking at a +1½ -113 line, providing a tempting opportunity for those betting on the underdog. The over/under for this game is set at 48, with the over priced at -113.
Broadcast on CBS, this is a must-watch game for any football fan. The Saints vs Bills odds have seen some movement since the opening lines, reflecting the competitive nature of both teams. For those looking to place a bet, understanding these odds and the factors influencing them is crucial. Ready to bet smarter? Start your OddsTrader Turbo subscription now or place your bet with a U.S. regulated sportsbook and profit off the edge.
Stay updated on all NFL odds by checking our NFL odds page regularly. With the insights provided, you can make informed decisions and find the best value bets.
Spread (FULL GAME)
COVER PROB.EXPECTED VALUEBEST LINE
New OrleansSpread
+2.2%
EV
+2.2%
BuffaloSpread
-7.0%
EV
-7.0%
MONEYLINE (FULL GAME)
COVER PROB.EXPECTED VALUEBEST LINE
New OrleansMONEYLINE
+5.0%
EV
+5.0%
BuffaloMONEYLINE
-8.5%
EV
-8.5%
Total (FULL GAME)
COVER PROB.EXPECTED VALUEBEST LINE
OVERTotal
-6.1%
EV
-6.1%
UNDERTotal
+1.5%
EV
+1.5%
Spread (1H)
BEST LINE
New OrleansSpread
BuffaloSpread
MONEYLINE (1H)
BEST LINE
New OrleansMONEYLINE
BuffaloMONEYLINE
Total (1H)
BEST LINE
OVERTotal
UNDERTotal
Spread (2H)
BEST LINE
New OrleansSpread
BuffaloSpread
MONEYLINE (2H)
BEST LINE
New OrleansMONEYLINE
BuffaloMONEYLINE
Total (2H)
BEST LINE
OVERTotal
UNDERTotal
Spread (1Q)
BEST LINE
New OrleansSpread
BuffaloSpread
MONEYLINE (1Q)
BEST LINE
New OrleansMONEYLINE
BuffaloMONEYLINE
Total (1Q)
BEST LINE
OVERTotal
UNDERTotal
Spread (2Q)
BEST LINE
New OrleansSpread
BuffaloSpread
MONEYLINE (2Q)
BEST LINE
New OrleansMONEYLINE
BuffaloMONEYLINE
Total (2Q)
BEST LINE
OVERTotal
UNDERTotal
Spread (3Q)
BEST LINE
New OrleansSpread
BuffaloSpread
MONEYLINE (3Q)
BEST LINE
New OrleansMONEYLINE
BuffaloMONEYLINE
Total (3Q)
BEST LINE
OVERTotal
UNDERTotal
Spread (4Q)
BEST LINE
New OrleansSpread
BuffaloSpread
MONEYLINE (4Q)
BEST LINE
New OrleansMONEYLINE
BuffaloMONEYLINE
Total (4Q)
BEST LINE
OVERTotal
UNDERTotal
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