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The Dallas Cowboys are set to take on the Carolina Panthers at the Bank of America Stadium in Charlotte, NC, on December 15, 2024. This NFL matchup kicks off at 1:00 PM EST and will be broadcast live on FOX. The Cowboys, who previously defeated the Panthers 33-10 in their last matchup, are looking to replicate their success. The Panthers, playing at home, have a 4-3 against the spread record, which you can see on our NFL standings page. Both teams are dealing with injuries, notably with the Cowboys' starting quarterback Dak Prescott on the IR list, meaning Cooper Rush will likely start. The Panthers' defense, despite injuries, is expected to be bolstered by the return of Jaycee Horn. With the point spread set at 3 points favoring the Panthers, this game promises to be a close contest. The over/under is at 42.5 points, making it a crucial factor for bettors considering the Panthers' recent trend of high-scoring games. With both teams' recent performances, bettors should consider the Panthers' strong home record and the Cowboys' struggles on the road. The best bet for this game is to take the Panthers with the spread.