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The highly anticipated NFL regular season opener between the Carolina Panthers and Jacksonville Jaguars is set for September 7, 2025, at EverBank Stadium in Jacksonville, FL. This Sunday football matchup promises excitement as both teams aim to kick off the season with a victory. Fans can catch the action live on FOX. The Panthers, looking to bounce back from a challenging previous season, will face the Jaguars, who have shown strong form lately. Our prediction suggests a close contest, with the Jaguars edging out the Panthers with a predicted score of 25-22. This aligns with our pick of Jacksonville -3.5, which boasts a hit rate of 50.6%. Our models have been profitable in recent games, particularly in point spread markets. Ready to make informed bets? Start your OddsTrader Turbo subscription now and check out our NFL picks page for more insights. The best odds for the Jaguars are also available at Jacksonville -3.5 at SugarHouse. With a predicted total score of 47, consider betting on the under 46.5 as a savvy move, given its competitive coverage percentage. Use these insights to make smarter betting decisions this season!