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Get ready for an exciting NFL matchup as the Chicago Bears take on the Detroit Lions on September 14, 2025, at Ford Field in Detroit, MI. This Sunday football clash is set to be broadcasted on Fox, making it a must-watch for fans and bettors alike. Our expert picks predict a narrow victory for the Detroit Lions, with a final score of 27-22. The Lions are favored with a spread of -6.5, while the over/under is set at 47 points. Historically, our picks have shown a strong hit rate, winning 6 out of the last 10 games in the American Total market. This consistency makes us confident in predicting an over for this game. Ready to make your move? Start your OddsTrader Turbo subscription now or place your bet with a U.S. regulated sportsbook for the best odds. For more insights, check out our NFL picks page and stay ahead of the game.