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FINAL
Dec 28, 2025 8:20 PM EST
CHI 38 vs SF 42
Week 17
SF
-4 (-115)o51½ (-110)
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Chicago Bears vs San Francisco 49ers Picks
Updated:Dec 28, 2025 1:33 AM EST
The NFL showdown on December 29, 2025, features the Chicago Bears vs San Francisco 49ers at Levi's Stadium in Santa Clara, CA. This Sunday night football game promises to be thrilling as the 49ers host the Bears in Week 17 of the 2025-26 NFL season. Fans can catch the action live on NBC and NBC Peacock. Our expert picks suggest a close contest with the 49ers favored to win 27-24 against the spread of -3.5 points for the Bears. The predicted total score is just under the line at 51.2, making the under 52 a smart betting tip for this matchup.
Our prediction model has been solid recently, boasting a hit rate of 58% on point spreads and a high EV of 5.6% on the Bears +3.5 spread in the last 10 games. Additionally, the under 52 market has shown a profitable cover percentage of 54.3% with a positive EV of 3.1%. These stats can help bettors make informed decisions and find value bets for this NFL Week 17 clash. For more expert insights, check out our full NFL picks and predictions to stay ahead of the game. Ready to bet smarter? Start your OddsTrader Turbo subscription now or place your bet with a U.S. regulated sportsbook and profit off the edge.
UPCOMING GAME PREDICTION
Spread
Money
Total
CHISpread
CONSENSUS LINE
+3½ (-110)
PROJECTION
SF (26) - CHI (24)
COVER PROBABILITY
EXPECTED VALUE
+6.8%
BET RATING
SEASON COVER %
10/15
67%
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