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Get ready for an exciting NFL showdown this September 14, 2025, as the Denver Broncos take on the Indianapolis Colts at Lucas Oil Stadium in Indianapolis, IN. This Week 2 clash promises a thrilling encounter with the Broncos slightly favored, holding a 59.3% win probability. The game will be broadcasted on CBS, making it a must-watch event for sports enthusiasts and bettors alike. Our prediction model suggests a close game, with a predicted score of 23-20 in favor of Denver. Historically, the Broncos have been strong contenders, and our model shows a high hit rate in predicting their outcomes. If you're looking to make smart bets, consider the Broncos' moneyline, which offers a positive EV. For more insights and picks, check out our comprehensive NFL picks page. Don't miss out on the action, and start your OddsTrader Turbo subscription to gain an edge over the competition.