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The Denver Broncos will face the New Orleans Saints at the Caesars Superdome in New Orleans on October 17th, 2024, at 8:15 PM ET, broadcasted live on Amazon Prime Video. With the Broncos' recent victory over the Raiders, and the Saints coming off a loss to the Buccaneers, this matchup promises to be intriguing. The Broncos have a strong record against the spread, performing well as an away team, as shown on our NFL standings page. In their last matchup on November 29th, 2020, the Saints dominated with a 31-3 victory over the Broncos. This time, the odds favor the Broncos with a -3 point spread (Caesars), and an over/under of 37 points. Notably, Bo Nix will start as quarterback for Denver, filling in for the injured Zach Wilson. The Saints, however, will miss several key players, including Chris Olave and Derek Carr, which could impact their offensive strategy. The Broncos have been effective with an average of 294 total yards per game offensively, while the Saints have struggled defensively, allowing an average of 394.857 total yards per game. For bettors, focusing on the point spread and the Broncos' away performance could be crucial.