N.Y. Giants vs Denver Broncos Picks for October 19

The upcoming NFL showdown on October 19, 2025, features the N.Y. Giants vs Denver Broncos at Empower Field at Mile High in Denver, CO. This Sunday football game is set to be broadcast live on CBS. Our picks for this matchup are backed by solid betting insights, with the Broncos favored to win with a predicted score of 22 to 16 against the Giants. The Broncos carry a strong recent record, having won 6 of their last 10 games covering key markets like the moneyline and point spreads with a hit rate of 70.8% and an EV of -7.9% on 2way bets, and a 47.2% hit rate with -3.8% EV on the spread at -7.5. Meanwhile, the Giants have a competitive 52.8% hit rate and a positive EV of 0.6% on the spread at +7.5, suggesting a close contest. The total score is predicted to be under 40.5, with a 55.9% hit rate and 3.5% EV, indicating a tight defensive battle. These stats and our predictions can help bettors make informed decisions and find value bets for this exciting NFL regular-season week 7 game. For a deeper dive into NFL picks and betting strategies, check out our comprehensive NFL picks and predictions. Ready to bet smarter? Start your OddsTrader Turbo subscription now or place your bet with a U.S. regulated sportsbook and profit off the edge.