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Get ready for an exciting start to the 2025 NFL season as the Detroit Lions face off against the Green Bay Packers on September 7, 2025, at Lambeau Field in Green Bay, WI. This matchup promises to be a thrilling Sunday night football game, broadcasted on CBS, where both teams aim to kick off their season with a win. Our picks favor the Packers to edge out the Lions with a predicted score of 23-21. The Lions have shown strong performance in their last games, boasting a hit rate of 73.6% against the spread, which indicates a competitive encounter. However, Green Bay's home advantage and a solid 54.8% win probability give them the upper hand. Our prediction model has consistently delivered positive results, particularly in 2way bets, where it has been profitable over the last 10 games. Expect a strategic showdown with a predicted total score under 47.5, aligning with our betting tips. Visit our NFL picks page for more insights and make smarter bets. Ready to bet smarter? Start your OddsTrader Turbo subscription now or place your bet with a U.S. regulated sportsbook and profit off the edge.