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The Indianapolis Colts will host the Green Bay Packers at Lucas Oil Stadium in Indianapolis, IN on August 16th, 2025. This preseason Week 2 matchup promises excitement as both teams look to fine-tune their rosters. The Colts, led by quarterback Anthony Richardson Sr., are slight favorites with a -6 point spread according to Caesars, reflecting their home advantage. The Packers, with Jordan Love listed as questionable due to a thumb injury, will rely on their backup quarterback, Sean Clifford, if Love doesn't play. In their last matchup on September 15th, 2024, the Packers defeated the Colts 16-10. The game will be broadcasted live on NFL+ at 1:00 PM ET. Check out our NFL standings page for more on their ATS records. With both teams having an ATS record of 0-0-0, this game could set the tone for their upcoming seasons. The total points line is set at 40, suggesting a potentially defensive battle.