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Before the clash on September 21, 2025, between the Houston Texans and Jacksonville Jaguars at EverBank Stadium in Jacksonville, FL, NFL fans and sports bettors are buzzing. Scheduled to broadcast on CBS, this game promises an exciting Sunday football showdown. The Texans are slightly favored with a predicted score of 24-22 against the Jaguars. Our prediction model, which has a solid hit rate in recent games, suggests betting on the Texans to cover the spread. With a projected total score of over 43.5, betting on the over could also be a wise choice. Our predictions have been profitable in similar markets, hitting a 55.8% success rate recently. Check out our detailed NFL picks for more insights. Ready to bet smarter? Start your OddsTrader Turbo subscription now and leverage your edge with a U.S. regulated sportsbook.