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The Tennessee Titans are set to face off against the Houston Texans on September 28, 2025, at NRG Stadium in Houston, TX. This NFL matchup, airing on CBS, promises to be an exciting clash. Our picks favor the Houston Texans with a predicted score of 23-15. The Texans' strong home advantage combined with a robust defense makes them a solid choice for bettors. Historically, the Texans have a hit rate of 77.9% on 2-way bets, making them a reliable pick this Sunday. Additionally, the under 39.5 total points market shows a promising EV of 3.0%, suggesting a lower scoring game. Our prediction model has been quite successful, winning 6 of the last 10 games under similar conditions. Ready to bet smarter? Start your OddsTrader Turbo subscription now or place your bet with a U.S. regulated sportsbook and profit off the edge. For more insights, check out our NFL picks page.