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Dec 22, 2025 8:15 PM EST
SF 48 vs IND 27
Week 16
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-4 (-113)o46½ (-115)
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49ers vs Colts Odds for Monday Night Football
Updated:Dec 22, 2025 1:24 AM EST
The upcoming Monday night football clash on December 22, 2025, between the San Francisco 49ers and the Indianapolis Colts at Lucas Oil Stadium in Indianapolis, IN promises an exciting NFL showdown. This highly anticipated game offers bettors a chance to capitalize on the latest odds and betting lines as both teams vie for a crucial regular-season victory.
Currently, the point spread favors the 49ers at -5½ -110, with the Colts as underdogs at +5½ -109. The opening odds were similar, indicating steady confidence in the 49ers maintaining their edge. The total over/under is set at 46 points with both sides at -110. Observing these odds and how they have moved can help bettors make informed decisions, especially when considering the strategic implications of the spread and total points.
For fans and bettors looking to catch all the action, the game will be broadcast on ESPN, ensuring prime-time coverage. Understanding these betting odds and lines is vital for making smart wagers, and you can dive deeper into NFL betting insights by visiting the NFL odds page. Ready to bet smarter? Start your OddsTrader Turbo subscription now or place your bet with a U.S. regulated sportsbook and profit off the edge.
Spread (FULL GAME)
COVER PROB.EXPECTED VALUEBEST LINE
San FranciscoSpread
-6.0%
EV
-6.0%
IndianapolisSpread
+2.3%
EV
+2.3%
MONEYLINE (FULL GAME)
COVER PROB.EXPECTED VALUEBEST LINE
San FranciscoMONEYLINE
-7.7%
EV
-7.7%
IndianapolisMONEYLINE
+5.2%
EV
+5.2%
Total (FULL GAME)
COVER PROB.EXPECTED VALUEBEST LINE
OVERTotal
-8.7%
EV
-8.7%
UNDERTotal
+2.1%
EV
+2.1%
Spread (1H)
BEST LINE
San FranciscoSpread
IndianapolisSpread
MONEYLINE (1H)
BEST LINE
San FranciscoMONEYLINE
IndianapolisMONEYLINE
Total (1H)
BEST LINE
OVERTotal
UNDERTotal
Spread (2H)
BEST LINE
San FranciscoSpread
IndianapolisSpread
MONEYLINE (2H)
BEST LINE
San FranciscoMONEYLINE
IndianapolisMONEYLINE
Total (2H)
BEST LINE
OVERTotal
UNDERTotal
Spread (1Q)
BEST LINE
San FranciscoSpread
IndianapolisSpread
MONEYLINE (1Q)
BEST LINE
San FranciscoMONEYLINE
IndianapolisMONEYLINE
Total (1Q)
BEST LINE
OVERTotal
UNDERTotal
Spread (2Q)
BEST LINE
San FranciscoSpread
IndianapolisSpread
MONEYLINE (2Q)
BEST LINE
San FranciscoMONEYLINE
IndianapolisMONEYLINE
Total (2Q)
BEST LINE
OVERTotal
UNDERTotal
Spread (3Q)
BEST LINE
San FranciscoSpread
IndianapolisSpread
MONEYLINE (3Q)
BEST LINE
San FranciscoMONEYLINE
IndianapolisMONEYLINE
Total (3Q)
BEST LINE
OVERTotal
UNDERTotal
Spread (4Q)
BEST LINE
San FranciscoSpread
IndianapolisSpread
MONEYLINE (4Q)
BEST LINE
San FranciscoMONEYLINE
IndianapolisMONEYLINE
Total (4Q)
BEST LINE
OVERTotal
UNDERTotal
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