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The Jacksonville Jaguars are favored to win today against the New Orleans Saints in Week 2 of the 2025-26 NFL preseason. The betting line on this game has the Jaguars with a point spread of -2½ -115, making them the favorites, while the Saints have a spread of +2½ -105. The current odds on the moneyline are -155 for the Jaguars and +130 for the Saints, indicating a strong probability for the Jaguars' victory. The total over/under is set at 40.5 points, with the over priced at -115. Discover the latest NFL Odds for this matchup to stay updated on any changes.