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The San Francisco 49ers are set to face the Kansas City Chiefs on October 20, 2024, at Levi's Stadium in Santa Clara, CA. This matchup, broadcasted on FOX, is a pivotal game for both teams. The 49ers, led by starting quarterback Brock Purdy, are looking to improve their current season record of 3-4-0. Meanwhile, the Chiefs, with star quarterback Patrick Mahomes, boast an impressive 6-0-0 record. In their last matchup on February 11, 2024, the Chiefs narrowly secured a win with a score of 25-22. The 49ers have struggled against the spread, standing at 3-4-0, whereas the Chiefs are strong at 4-1-1, as seen on our NFL standings page. The current point spread is 2.5 in favor of the 49ers, with a total points line set at 48. Both teams have key injuries, with the 49ers missing Christian McCaffrey and Deebo Samuel being questionable. This game promises to be a thrilling encounter, with the Chiefs' offensive prowess against the 49ers' resilient defense.