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Prepare for an exhilarating NFL showdown as the Las Vegas Raiders take on the New England Patriots on September 7, 2025, at Gillette Stadium in Foxborough, MA. Scheduled for a 1:00 PM ET kickoff and broadcasted on CBS, this clash marks the opening week of the 2025-26 NFL season. Both teams are eager to start their campaigns with a victory. The Patriots, playing at home, are slightly favored with a -2.5 spread, while our prediction model suggests a narrow 22-21 win for New England. Our betting insights highlight the under 44 market as a promising pick for this game, with a strong 55.0% hit rate and a positive EV of 2.6%. Over the last 10 games, our predictions have shown profitability, particularly in the American Total market. This matchup promises to be a tactical battle, with both teams showcasing their strengths and strategies. Don't miss out on the action! Check out our comprehensive NFL picks page for more expert analysis and predictions. Ready to bet smarter? Start your OddsTrader Turbo subscription now or place your bet with a U.S. regulated sportsbook and profit off the edge.