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FINAL OT
Oct 2, 2025 8:15 PM EDT
SF 26 vs LA 23
Week 5
LA
-8 (-110)o43½ (-110)
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San Francisco 49ers vs L.A. Rams Picks
Updated:Sep 30, 2025 3:32 AM EDT
Excited for Thursday night football? On October 2, 2025, the San Francisco 49ers face off against the Los Angeles Rams at SoFi Stadium in Inglewood, CA. This NFL showdown promises thrilling action, as the Rams host the 49ers with an enticing pick spread. Broadcasting live on Amazon Prime Video, it's a game you won't want to miss. Our expert predictions favor the Rams with a predicted score of 26-21 against the 49ers, making the L.A. Rams -4 a solid pick. Historically, our predictions have been profitable, with a high EV and a consistent hit rate. Explore more NFL picks. Start your OddsTrader Turbo subscription today for smarter bets!
UPCOMING GAME PREDICTION
Spread
Money
Total
SFSpread
CONSENSUS LINE
+8½ (-112)
PROJECTION
LA (25) - SF (18)
COVER PROBABILITY
EXPECTED VALUE
+2.8%
BET RATING
SEASON COVER %
2/4
50%
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