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The San Francisco 49ers are set to face the New England Patriots on September 29, 2024, at Levi's Stadium in Santa Clara, CA. The game starts at 16:05 EDT and will be broadcast on FOX. The 49ers, coming off a strong 30-13 victory in their last matchup against the Patriots on October 25, 2020, are currently favored by -6.5 points. San Francisco’s offense, led by quarterback Brock Purdy, has been impressive, averaging 25.8 points per game and ranking 2nd in total yards. On the other hand, New England, quarterbacked by Jacoby Brissett, has struggled offensively, ranking 32nd in total yards and averaging just 13 points per game. The Patriots' defense will need to step up significantly to contain the 49ers' high-powered offense. For detailed ATS records, visit our NFL standings page.