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The San Francisco 49ers are set to face the Seattle Seahawks in a thrilling NFL matchup at Lumen Field in Seattle, WA. The game will be broadcast live on Amazon Prime at 8:15 PM ET on October 10, 2024. Both teams are coming off mixed performances in recent games, with the 49ers holding a 2-3 record and the Seahawks at 3-2. In their last matchup on December 10th, 2023, the 49ers triumphed over the Seahawks 28-16. Starting quarterbacks Brock Purdy for the 49ers and Geno Smith for the Seahawks will be pivotal in this game. The 49ers are favored with a -3.5 point spread, as seen on our NFL standings page. Key players like Nick Bosa for the 49ers and DK Metcalf for the Seahawks will be crucial. The total points line is set at 49.5, suggesting a potentially high-scoring affair. However, the 49ers have shown defensive prowess, allowing only 307.8 total yards per game, while the Seahawks have averaged 270.8 passing yards offensively. Betting enthusiasts should consider the 49ers' strong defensive stats against the Seahawks' potent offense when making decisions.