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Oct 12, 2025 4:25 PM EDT
SF 19 vs TB 30
Week 6
TB
-3½ (-105)o47 (-110)
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49ers vs Buccaneers: NFL Odds & Betting Lines
Updated:Oct 12, 2025 2:28 AM EDT
As we gear up for the 2025 NFL season, the San Francisco 49ers are set to take on the Tampa Bay Buccaneers on October 12, 2025, at Raymond James Stadium in Tampa, FL. This matchup promises to be an electrifying game, with both teams looking to make a statement in Week 6. The Buccaneers, playing at home, are the favorites with a point spread of -3½ -106, according to Caesars, while the 49ers are looking to pull an upset with a spread of +3½ -115. The over/under is set at 47, offering plenty of action for bettors.
The 49ers vs Buccaneers game is a must-watch for NFL fans and bettors alike. Broadcasted on CBS, this game is a prime opportunity to dive into the latest betting lines and make informed wagers. With Tampa Bay's strong home-field advantage, the odds are in their favor, but San Francisco's resilience could lead to a thrilling contest.
For those looking to place bets, the best odds for the Buccaneers are -179 on the Moneyline at Caesars. Meanwhile, the 49ers offer a tempting +145. To make the most of this game, Start your OddsTrader Turbo subscription or explore our NFL odds page for more insights.
Spread (FULL GAME)
COVER PROB.EXPECTED VALUEBEST LINE
San FranciscoSpread
-0.3%
EV
-0.3%
Tampa BaySpread
-3.6%
EV
-3.6%
MONEYLINE (FULL GAME)
COVER PROB.EXPECTED VALUEBEST LINE
San FranciscoMONEYLINE
+6.1%
EV
+6.1%
Tampa BayMONEYLINE
-10.1%
EV
-10.1%
Total (FULL GAME)
COVER PROB.EXPECTED VALUEBEST LINE
OVERTotal
-5.9%
EV
-5.9%
UNDERTotal
+0.7%
EV
+0.7%
Spread (1H)
BEST LINE
San FranciscoSpread
Tampa BaySpread
MONEYLINE (1H)
BEST LINE
San FranciscoMONEYLINE
Tampa BayMONEYLINE
Total (1H)
BEST LINE
OVERTotal
UNDERTotal
Spread (2H)
BEST LINE
San FranciscoSpread
Tampa BaySpread
MONEYLINE (2H)
BEST LINE
San FranciscoMONEYLINE
Tampa BayMONEYLINE
Total (2H)
BEST LINE
OVERTotal
UNDERTotal
Spread (1Q)
BEST LINE
San FranciscoSpread
Tampa BaySpread
MONEYLINE (1Q)
BEST LINE
San FranciscoMONEYLINE
Tampa BayMONEYLINE
Total (1Q)
BEST LINE
OVERTotal
UNDERTotal
Spread (2Q)
BEST LINE
San FranciscoSpread
Tampa BaySpread
MONEYLINE (2Q)
BEST LINE
San FranciscoMONEYLINE
Tampa BayMONEYLINE
Total (2Q)
BEST LINE
OVERTotal
UNDERTotal
Spread (3Q)
BEST LINE
San FranciscoSpread
Tampa BaySpread
MONEYLINE (3Q)
BEST LINE
San FranciscoMONEYLINE
Tampa BayMONEYLINE
Total (3Q)
BEST LINE
OVERTotal
UNDERTotal
Spread (4Q)
BEST LINE
San FranciscoSpread
Tampa BaySpread
MONEYLINE (4Q)
BEST LINE
San FranciscoMONEYLINE
Tampa BayMONEYLINE
Total (4Q)
BEST LINE
OVERTotal
UNDERTotal
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