Jake Brendel Injury News & Updates
Keep up with the latest injuries from the Titans vs 49ers game on Sunday with our National Football League injury report.Nov 7, 2025
Returning to action in Week 10
Brendel (hamstring) does not have an injury designation for Sunday's battle against the Rams, Nick Wagoner of ESPN.com reports.
ANALYSIS
Brendel hurt his hamstring in Week 7 against Atlanta and missed San Francisco's subsequent two contests. However, he was able to log an LP/LP/FP practice progression this week and has been given clearance to return to action Sunday. Matt Hennessy has done a serviceable job filling in at center the past two weeks, but Brendel figures to retake his starting role against the Rams.
Oct 31, 2025
Sidelined again
Brendel (hamstring) was ruled out ahead of Sunday's matchup against the Giants,Jennifer Lee Chan of NBC Sports Bay Area reports.
ANALYSIS
Brendel originally suffered the injury in Week 7 against the Falcons and will be set for his second consecutive absence. He has yet to practice since dealing with the injury.
Oct 29, 2025
Sits out practice
Brendel (hamstring) didn't participate in San Francisco's practice Wednesday, Eric Branch of the San Francisco Chronicle reports.
ANALYSIS
Brendel remains sidelined with the knee injury he suffered in the team's Week 7 win over the Falcons. Matt Hennessy will start at center for the second straight week if Brendel is unable to suit up for Sunday's matchup against the Giants.
Oct 24, 2025
Won't play Sunday
Brendel (hamstring) is listed as out for Sunday's game at Houston, Nick Wagoner of ESPN.com reports.
ANALYSIS
Brendel will miss his first game of the season in Week 8 due to a hamstring injury he suffered in Week 7 versus the Falcons. In his absence, Matt Hennessy projects to start at center Sunday at Houston.
Oct 20, 2025
Expected to miss time with injury
Head coach Kyle Shanahan said Monday that Brendel is expected to be sidelined for a couple of weeks due to a hamstring injury, Matt Maiocco of NBC Sports Bay Area reports.
ANALYSIS
Brendel sustained the injury during the 49ers' 20-10 win over the Falcons on Sunday. He started at center in each of the first seven games of the regular season, and his absence means Matt Hennessy will likely take over the as the 49ers' center for as long as Brendel is on the shelf.
Oct 19, 2025
Ruled out Sunday night
Brendel has a hamstring injury and has been ruled out for the rest of Sunday night's matchup with the Falcons, Matt Maiocco of NBC Sports Bay Area reports.
ANALYSIS
The veteran has started all seven games this season and every 49ers game dating back to 2021. Matt Hennessy is his backup.
Mar 14, 2023
Back with 49ers on four-year pact
Brendel and the 49ers agreed to terms on a four-year contract Tuesday, NFL Network's Ian Rapoport reports.
ANALYSIS
Brendel became a full-time starter as a 30-year-old last season, making all 17 starts at center after starting just three career contests prior to 2022. It's a big keep for the Niners after they reportedly lost stalwart RT Mike McGlinchey to the Broncos on Monday.
Sep 2, 2021
Back with 49ers
Brendel signed a contract with the 49ers on Wednesday.
ANALYSIS
Brendel was cut by San Francisco ahead of Tuesday's roster deadline but re-signed with the team a day later. The 28-year-old opted out of the 2020 campaign and should provide depth at center for the 49ers.
Aug 6, 2020
Opts out of 2020 season
Brendel has opted out of the 2020 season, Nick Wagoner of ESPN.com reports.
ANALYSIS
The journeyman center spent time with in Dallas, Miami, Denver and Baltimore before signing a contract with the 49ers earlier this year. He is the third member of the 49ers to opt out of the season.
Feb 10, 2020
Scooped up by San Francisco
Brendel signed a contract with the 49ers on Monday.
ANALYSIS
Brendel was cut loose by the Ravens at the end of November, but he'll now get a shot with San Francisco to win a roster spot. He's bounced around since being signed by the Cowboys as an undrafted free agent in 2016, spending time in Dallas, Miami, Denver and Baltimore.
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