There will be four NFL games played before Sunday this week! It’s ultimately Thanksgiving Weekend, with three games on Thursday and one on Black Friday.
So, while the Sunday slate will be smaller, we’ve got some exciting football throughout the entire weekend, starting on Thursday.
I’ll discuss some of the top NFL odds Week 13. Just make sure to check out the football betting lines for all NFL games at OddsTrader now!
NFL Odds Week 13 At-a-Glance
The storylines are crazy heading into Week 13. We could see Joe Burrow back in action for the Bengals.
Plus, Shedeur Sanders won his first game under center with the Browns, but Dillon Gabriel will likely be healthy enough to play for Cleveland on Sunday. Would the Browns bench Sanders for Gabriel despite last week’s win?
Let’s discuss some of the NFL odds for Week 13.
Cincinnati Bengals vs. Baltimore Ravens (-7 -120)
Thursday, November 27, 2025 – 08:20 PM ET
The Bengals almost activated Joe Burrow to start against the Patriots last week. Ultimately, he didn’t play, and Joe Flacco made some terrible mistakes that led to New England’s victory.
Nobody would be shocked if Burrow plays this weekend against the Ravens. Plus, Ja’Marr Chase will return from his suspension. Since Tee Higgins has a concussion, Chase would be the go-to guy.
Meanwhile, the Ravens escaped the Jets last weekend. Lamar Jackson played terribly, but it was still enough to get by against the Jets. If he continues his poor play, the Bengals have a legitimate chance to knock off the Ravens on Thursday Night Football.
San Francisco 49ers vs. Cleveland Browns (+6 -120)
Sunday, November 30, 2025 – 01:00 PM ET
Yes, Shedeur Sanders helped the Cleveland Browns defeat the Las Vegas Raiders last week. No, Sanders wasn’t excellent. He was 11-for-20 from the field and threw one touchdown with an interception. His QBR was under 10, and he really didn’t have to do much to get the win.
The defense earned 10 sacks and forced the Raiders to fire Chip Kelly after the game. Sanders made some great throws, but he might not even play next week with Dillon Gabriel returning from a concussion.
On the other hand, the 49ers still have a game against the Panthers tonight. It’s likely the 49ers win over Carolina with Brock Purdy back under center. Ultimately, the Browns won’t be good enough to get by most teams. One of those teams is San Francisco.
New York Giants vs. New England Patriots (-7.5 -110)
Sunday, November 30, 2025 – 08:15 PM ET
The New York Giants have fired defensive coordinator Shane Bowen after another tight loss last weekend. The Giants have had the lead by multiple scores many times this season, but haven’t been able to hold it.
The offense has to do its part, but the defense needs to find ways, too. They’re way too talented to be struggling week after week. They run out of gas every game in the fourth quarter.
With a new alignment and strategy, the Giants should excel. Plus, Jaxson Dart will likely return to the field and help give New York some juice.
New England has won many games in a row. But on Monday Night Football, random things happen. Consider the Giants at +7.5 (-120).
Place Your Week 13 Bets Now!
There are odds for all NFL games up on OddsTrader right now.
I’ve added my recommendations above. But feel free to bet on any game where you see fit. Value is value!
Make sure to download the free-to-use OddsTrader App, which will allow you to view odds, picks, and props anywhere, anytime. The NFL odds Week 13 will change over time, so make your bets before the odds change against you.
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*The line and/or odds referenced in this article might have changed since the content was published. For the latest information on line movements, visit OddsTrader’s free betting odds tool.
