Eastern Illinois Panthers vs Iowa State Cyclones Betting Trends

The upcoming NCAA basketball game on December 14, 2025, between the Eastern Illinois Panthers and Iowa State Cyclones at James H. Hilton Coliseum in Ames, IA promises an exciting betting opportunity. The Iowa State Cyclones have been dominant this season with a perfect 10-0 straight-up record and are strong at home with an 8-0 record. Their defensive rating of 90.87 and 3-point shooting percentage of 43.1% highlight their offensive and defensive balance. The Eastern Illinois Panthers, struggling with a 2-7 straight-up record and 3-4-1 against the spread, face a tough challenge. Their 3-point shooting percentage is a modest 28.2%, and they allow 114.98 points on defense, indicating defensive vulnerabilities.

Key players from both teams will influence the game, with Iowa State's starting five expected to perform well, given their recent form. Eastern Illinois has a questionable starter who is likely to play, which could affect their gameplay. The point spread is heavily in favor of Iowa State at -41.5, with a total points over/under set at 143.5. This significant spread suggests Iowa State is expected to dominate, making the best bet leaning towards Iowa State to cover the spread. The game will be broadcast on ESPN+, providing fans and bettors with comprehensive coverage.

In their last matchup on December 21, 2023, Iowa State decisively beat Eastern Illinois 80-48, covering a -31.5 spread. This historical context, combined with current season stats and betting insights, supports confidence in Iowa State's strong performance. Bettors can check the latest odds and consider starting an OddsTrader Turbo subscription to gain an edge. Ready to bet smarter? Start your OddsTrader Turbo subscription now or place your bet with a U.S. regulated sportsbook and profit off the edge.